- HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE
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The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
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Page/Page column 210
(2011/10/05)
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- HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE
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The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
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Page/Page column 99
(2010/06/11)
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- Benzo[4,5]imidazo[2,1-a]phthalazines: I. Substituted o- nitrophenylhydrazines in the synthesis of phthalazin-1(2H)-ones
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Efficient cyclization procedure was developed for 2-nitro-, 2,4-dinitro-, 2-nitro-5-chloro-, and 4,5-dichloro-2-nitrophenylhydrazines with 2-acylbenzoic acids by heating the reagents in a mixture of of concentrated sulfuric acid and ethanol. A series of n
- Kuznetsov,Shubin,Shchipalkin,Teplyakov,Petrov
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experimental part
p. 731 - 735
(2009/04/07)
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- Competitive Cyclisations of Singlet and Triplet Nitrenes. Part 8. The 1-(2-Nitrenophenyl)pyrazoles and Related Systems
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The title nitrenes, derived by nitro-group deoxygenation with triethyl phosphite or by thermolysis or photolysis of the corresponding azide, have been studied.The effect of substituents (Cl, Br, OMe, NMe2, Me, CF3, and NO2) both meta and para to the nitrene has been examined as a determinant of the preferred mode of cyclisation to either a pyrazolobenzotriazole or a pyrazoloquinoxaline.Similarly, the role of solvents, sensitisers, and quenchers has been studied.Routes to the isomeric 1- and 2-(2-nitrophenyl)-4,5,6,7-tetrahydroindazoles have been defined and the literature corrected by studing the nitrene-mediated cyclisation of these products.The chemistry of the analogous 1-(2-carbenophenyl)- and the 1-(2-nitrenosulphonylphenyl)-3,5-dimethylpyrazoles has also been examined, the former giving 2-(3,5-dimethylpyrazol-1-yl)-benzaldazine and -benzyl alcohol while the latter gave products of intramolecular nitrene attack (a pyrazolobenzothiatriazine) and intermolecular reaction.Rationalisations for all the reaction pathways have been advanced.
- Lindley, John M.,McRobbie, Ian M.,Meth-Cohn, Otto,Suschitzky, Hans
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p. 982 - 994
(2007/10/02)
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