- Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents
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Discovery of 5-(1.1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5- dihydroisoxazole-3-carboxamides as a new class of malonyl-coenzyme A decarboxylase (MCD) inhibitors is described. tert-Butyl 3-(5-(1,1,1.3,3,3- hexafluoro-2-hydroxypropan-2-yl)-4,5-dihydroi
- Cheng, Jie-Fei,Huang, Yujin,Penuliar, Richard,Nishimoto, Masahiro,Liu, Larry,Arrhenius, Thomas,Yang, Guang,O'Leary, Eoin,Barbosa, Miguel,Barr, Rick,Dyck, Jason R. B.,Lopaschuk, Gary D.,Nadzan, Alex M.
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- 1-Bromo-4,4,4-trifluoro-3-(trifluoromethyl)but-2-ene: synthesis and electrophilic reactivity
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A two step synthesis of 1-bromo-4,4,4-trifluoro-3-(trifluoromethyl)but-2-ene in 35percent overall yield is reported starting from commercially available hexafluoroacetone.The electrophilic reactivity of this new compound towards various nucleophilic reage
- Valerie, Martin,Molines, Huguette,Wakselman, Claude
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