Concerning the Generality of the Temperature Dependence of Carbon-13 Shieldings as a Probe for Conformational or Structural Equilibria
In order to assess the effect of the chair-twist equilibrium in six-membered rings on the temperature dependence of 13C chemical shifts, we have examined a series of hydrocarbons and heterocycles with zero, one, or two geminal dimethyl groups.The temperat
Lambert, Joseph B.,Vagenas, Adelia R.,Somani, Sujata
Synthetic approaches to physiologically active polycyclic compounds: VI. Synthesis of 1-[(2R,3S)-N-benzoyl-phenylisoseryloxy]-4,4-dimethyladamantane
A convenient procedure was proposed for the synthesis of 4,4-dimethyladamantan-1-ol from 2-adamantanone. Esterification of the product with protected amino acid gave 1-[(2R,3S)-N-benzoylphenyl-isoseryloxy]-4,4- dimethyladamantane.
Zefirova,Nurieva,Zyk
p. 1286 - 1288
(2007/10/03)
Direct Geminal Dimethylation of Ketones using Dimethyltitanium Dichloride
Ketones are readily converted into the corresponding geminal dimethyl derivatives on reaction with dimethyltitanium dichloride under mild conditions; tertiary alcohols react similarly.