cas 199105-19-6, N-[2-(PIPERAZIN-1-YL)PHENYL]METHYLSULPHONAMIDE HYDROCHLORIDE | Articles data ｜lookchem

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199105-19-6

Articles about 199105-19-6Total 3 be found

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Synthesis and evaluation of a novel class Hsp90 inhibitors containing 1-phenylpiperazine scaffold
Previously, we identified 1-(2-(4-bromophenoxy)ethoxy)-3-(4-(2- methoxyphenyl)piperazin-1-yl)propan-2-ol (1) as a novel Hsp90 inhibitor with moderate activity through virtual screening. In this study, we report the optimization process of 1. A series of analogues containing the 1-phenylpiperazine core scaffold were synthesized and evaluated. The structure-activity relationships (SAR) for these compounds was also discussed for further molecular design. This effort afforded the most active inhibitor 13f with improved activity in not only target-based level, but also cell-based level compared with the original hit 1.
Jia, Jian-Min,Liu, Fang,Xu, Xiao-Li,Guo, Xiao-Ke,Jiang, Fen,Cherfaoui, Bahidja,Sun, Hao-Peng,You, Qi-Dong
p. 1557 - 1561
(2014/03/21)

Aryl piperazine melanocortin MC4 receptor agonists
Incorporation of substituted phenyl piperazine privileged structures into a known MC4 specific dipeptoid consensus sequence resulted in a series of potent (EC50=24 nM) and selective MC4-R agonists. We report the SAR of this series of compounds
Dyck, Brian,Parker, Jessica,Phillips, Teresa,Carter, Lee,Murphy, Brian,Summers, Robin,Hermann, Julia,Baker, Tracy,Cismowski, Mary,Saunders, John,Goodfellow, Val
p. 3793 - 3796
(2007/10/03)

Serine derived NK1 antagonists 2: A pharmacophore model for arylsulfonamide binding
Modifications to the spirocyclic aryl sulfonamide portion of serine derived NK1 antagonists allow a partial pharmacophore model to be developed.
Elliott,Broughton,Cascieri,Chicchi,Huscroft,Kurtz,MacLeod,Sadowski,Stevenson
p. 1851 - 1856
(2007/10/03)

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1579960-78-3
N-(2-(4-(3-(2-(4-bromophenoxy)ethoxy)-2-hydroxypropyl)piperazin-1-yl)phenyl)methanoesulfonamide

Chemical Properties

Boiling Point: 452.5oC at 760 mmHg
Flash Point:227.5oC
Density: 1.288±0.06 g/cm3(Predicted)
Vapor Pressure: 1.36E-08mmHg at 25°C
PKA: 10.02±0.10(Predicted)
PSA: 69.82000
LogP: 2.81730

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