- Synthesis of substituted 2-amino-1-arylidenaminoimidazoles and 1-arylidenaminoimidazo[1,2-a]imidazoles
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A new method is proposed for the preparation of 2-amino-1-arylidenaminoimidazoles, which react with α-haloketones to give a series of 1-arylidenamino-3-acylmethyl-2-iminoimidazolines and 1-arylidenaminoimidazo[1,2-a]imidazoles depending on the conditions. 1997 Plenum Publishing Corporation.
- Krimer,Makaev,Styngach,Koretskii,Pogrebnoi,Kochug
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p. 1035 - 1039
(2007/10/03)
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- Method for inhibiting advanced glycosylation of proteins using aminosubstituted imidazoles
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The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging), Accordingly, a composition is disclosed which comprises 2-aminoimidazoles capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation, The method comprises contacting the target protein with the composition, Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
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