Design, synthesis, biological evaluation of thiazolyl schiff base derivatives as novel anti-inflammatory agents
A series of new 4-(4-substitutedphenyl)-N-(4-substitutedbenzylidene)- thiazol-2-amine derivatives 5a-l has been synthesized and evaluated for their anti-inflammatory and analgesic activities at a dose of 50 mg/kg p.o. The most active compounds 5a, 5j have been subjected to acute ulcerogenesis study at a dose of 150 mg/kg. The structure of all these compounds have been established on the basis of spectral (IR, 1H NMR data) studies.
Bhosale,Chavan,Bhosale
p. 1649 - 1654
(2013/01/15)
Formation of azomethines from 2-aminothiazoles and (heterocyclic) aromatic aldehydes
Reexamination of previous work and new studies show that the reactions of 2-aminothiazoles with (heterocyclic) aromatic aldehydes are not straightforward; there are wide divergencies in behaviour between the various amine-aldehyde pairs. Simple efficient
Hopkinson,Meakins,Purcell
p. 621 - 624
(2007/10/02)
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