- SMALL MOLECULE INHIBITORS OF KYNURENINE-3-MONOOXYGENASE
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The present invention relates to compounds of formula (Ia) or (Ib) and their tautomers and/or pharmaceutically acceptable salts and compositions and methods of uses thereof.
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Page/Page column 59
(2008/06/13)
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- Use of N-(4-aryl-thiazol-2-yl)-sulfonamides
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The invention is concerned with the use of sulfonamide derivatives of the general formula STR1 wherein R signifies lower-alkyl, phenyl, benzyl, naphthyl, pyridyl or thienyl, optionally substituted by one or more lower-alkyl, lower-alkoxy, lower-alkyl carb
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- Synthesis and biochemical evaluation of N-(4-phenylthiazol-2- yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3- hydroxylase
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In this paper we describe the synthesis, structure-activity relationship (SAR), and biochemical characterization of N-(4-phenylthiazol-2- yl)benzenesulfonamides as inhibitors of kynurenine 3-hydroxylase. The compounds 3,4-dimethoxy-N-[4-(3-nitrophenyl)thi
- R?ver, Stephan,Cesura, Andrea M.,Huguenin, Philipp,Kettler, Rolf,Szente, Andre
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p. 4378 - 4385
(2007/10/03)
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