Water excellent solvent for the synthesis of bifunctionalized cyclopentenones from furfural
Chiral cyclopentenones are important precursors in the asymmetric synthesis of target molecules. In particular, C-2 amino cyclopentenones could be utilised as intermediates towards antitumor natural products. On the basis of our previous experience, we re
ONE-STEP SYNTHESIS OF 2-AMINO-3-FURANCARBOXYLIC ACID DERIVATIVES FROM 2-FURANCARBALDEHYDE
Reaction of derivatives of 2-furancarbaldehyde or 2-acetylfuran with malononitrile, methyl cyanoacetate or cyanoacetamide in the presence of secondary amines afforded derivatives of 2-amino-3-furancarboxylic acid in 45 - 88percent yields.