Benzathine is prepared in good yields from cyanobenzene by a combination of electrochemical hydrogenation and Kolbe electrolysis using nickel and platinum electrodes in the presence of methanolic sodium methoxide in an undivided cell.
Convenient synthesis of 4-trifluoromethyl-substituted imidazole derivatives
Mesoionic 4-trifluoroacetyl-1,3-oxazolium-5-olates (1), obtained from the reaction of N-acyl-N-alkylglycines (2) with trifluoroacetic anhydride, react with ammonia to give 4-trifluoromethyl-3,4-dihydroimidazoles (3) in high yields. Dehydration of 3 gives
Kawase,Saito,Kurihara
p. 461 - 464
(2007/10/03)
The Alkylation of Menthyl Hippurate and Some Related Materials: A Reinvestigation.
Benzylation of chiral esters of N-acyglycines using various bases and additives was examined.No C-alkylation was observed with one equivalent of base.Diastereoselectivities were dependent on the amount of additive, the nature of the N-acyl group, and the chiral ester.A model to account for the degree and sense of the stereoselectivity is proposed.
McIntosh, John M.,Thangarasa, Rasiah,Foley, Nancy K.,Ager, David J.,Froen, Diane E.,Klix, Russell C.
p. 1967 - 1974
(2007/10/02)
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