- Addition of organolithium reagents to some carbohydrate enones
-
Addition of organolithium reagents to die sugar enones: alkyl 2,3,6-trideoxy-α-L- and 2,3-dideoxy-α- D-hex-2-enopyranosid-4-ulose has been examined. Butyl, benzyl and 2,5-dimethoxy-4-methylphenyllithium add, with increasing stereoselectivity, to the carbonyl group of the α,β-unsaturated ketosugars, whereas 2,5-dimethoxybenzyllithium undergoes stereospecific conjugate addition and 1,2-addition in die ratio of 1.7:1. The structure of the resultant carbinols is based on X-ray crystallographic evidence.
- Achmatowicz, Osman,Szechner, Barbara,Maurin, Jan K.
-
p. 6035 - 6044
(2007/10/03)
-
- Mono and bis(bioreductive) alkylating agents: Synthesis and antitumor activities in a B16 melanoma model
-
Several potentially bis(alkylating) bis(quinones) (3-5) and 1,4- and 1,3-bis(alkylating) monoquinones (6-13) belonging to general structure 2,2'-ethylenebis[5-[(leaving group) methyl]-1,4-benzoquinone] (3-5) and 2,5- and 2,6-bis[(leaving group)methyl]-1,4
- Witiak,Loper,Ananthan,Almerico,Verhoef,Filppi
-
p. 1636 - 1642
(2007/10/02)
-