Practical synthesis of Abbott amino-diol: A core unit of the potent renin inhibitor Zankiren
Abbott amino-diol (2S,3R,4S)-2-amino-1-cyclohexyl-6-methyl heptane-3,4- diol 1, a main structural constituent of the orally active renin inhibitor Zankiren has been synthesized using Sharpless asymmetric aminohydroxylation as the key step.
Chandrasekhar,Mohapatra, Suchismita,Yadav
p. 4763 - 4768
(2007/10/03)
Neighbouring group assisted sulfonamide cleavage of sharpless aminols under acetonation conditions
It is accidentally observed that N-Ts cleavage and simultaneous protection of resulting free amino group as acetonide with the adjacent hydroxy group is achieved in one pot. Neighbouring carboxylic ester group is essential for this transformation.
Chandrasekhar,Mohapatra, Suchismita
p. 695 - 698
(2007/10/03)
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