- Palladium-Catalyzed ortho-Benzoylation of Sulfonamides through C?H Activation: Expedient Synthesis of Cyclic N-Sulfonyl Ketimines
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The ortho-carbonylation of sulfonylarenes by non-hazardous aryl aldehydes as a carbonyl precursor was reported. In this method, the sulfonamide group serves as a directing group for C?H activation in the presence of a Pd catalyst under ligand-free conditions. The scope of this strategy has been extended to the one-pot two-step synthesis of cyclic N-sulfonyl ketimines under mild reaction conditions. Our approach could be considered as an alternative by circumventing the use of highly reactive organolithium or Grignard reagents to access a wide range of biologically potent cyclic N-sulfonyl ketimines. (Figure presented.).
- Ojha, Subhadra,Panda, Niranjan
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p. 561 - 571
(2019/12/24)
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- A Facile One-Pot Procedure for the Synthesis of 1,2-Benzisothiazole 1,1-Dioxides
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ortho-Lithiated N,N-diphenylbenzenesulfonamides 6 react with aromatic nitriles and N,N-dimethylcarbamonitrile, respectively, to give directly the corresponding 3-substituted 1,2-benzisothiazole-1,1-dioxides 8a-f.Other cyano compounds only transfer the cyano group or its ligands to generate the o-substituted benzenesulfonamides 9a-d.
- Hellwinkel, D.,Karle, R.
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p. 394 - 395
(2007/10/02)
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