- Indoline and piperazine containing derivatives as a novel class of mixed D2/D4 receptor antagonists. Part 1: Identification and structure-activity relationships
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Optimization of the lead compound 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihydro-indol-1-yl)-ethanone 1 by systematic structure-activity relation (SAR) studies lead to two potent compounds 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2-methy-2,3-dihydro-indol-1-yl)- ethanone 2n and 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2-methy-2,3-dihydro-indol-1-yl)- ethanone 7b. Their related synthesis was also reported.
- Zhao, He,Thurkauf, Andrew,He, Xiaoshu,Hodgetts, Kevin,Zhang, Xiaoyan,Rachwal, Stanislaw,Kover, Renata X.,Hutchison, Alan,Peterson, John,Kieltyka, Andrzej,Brodbeck, Robbin,Primus, Renee,Wasley, Jan W.F.
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p. 3105 - 3109
(2007/10/03)
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- 1,2-Dihydro-1-oxopyrrolophenothiazine-2-carboxamides and Congeners, Dual Cyclooxygenase/5-Lipoxygenase Inhibitors with Antiinflammatory Activity
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A series of 1,2-dihydro-1-oxopyrrolophenothiazine, 1,2-dihydro-1-oxopyrrolophenoxazine, and 1,2-dihydro-1-oxopyrroloacridine-2-carboxamides were prepared by reaction of 1,2-dihydro-1-oxopyrrolophenothiazine or other
- Mylari, Banavara L.,Carty, Thomas J.,Moore, Peter F.,Zembrowski, William J.
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p. 2019 - 2024
(2007/10/02)
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