New carboxyalkyl inhibitors of brain enkephalinase: Synthesis, biological activity, and analgesic properties
New carboxylalkyl compounds derived from Phe-Leu and Phe-Ala were synthesized and checked as inhibitors of enkephalinase, a metalloendopeptidase cleaving the Gly3-Phe4 bond of enkephalins from mouse striatal membranes. Differential r