- Study of the 'dry reaction' without any medium under microwave irradiation
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Several reactions were conducted under microwave irradiation at ambient pressure, in the absence of solvent and any inorganics as catalyst carrier. Reaction time was dramatically reduced and good yield was obtained (compared with that of using organic sol
- Rongshun,Pinjie,Shushan
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- Asymmetric Total Synthesis and Biological Evaluation of (+)-Cycloclavine
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The first total synthesis of natural (+)-cycloclavine uses a catalytic asymmetric cyclopropanation of allene, a regiospecific Pd-catalyzed enone formation, and two intramolecular Diels-Alder reactions for indole/indoline annulations. The binding properties of natural (+)- and unnatural (-)-cycloclavine on 16 CNS receptors revealed significant stereospecificity and unique binding profiles in comparison to LSD, psilocin, and DMT. Differential 5-HT affinities, as well as novel sigma1 receptor properties bode well for potential therapeutic developments of clavine alkaloid scaffolds.
- McCabe, Stephanie R.,Wipf, Peter
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p. 213 - 224
(2019/01/04)
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- 4,7-Diphenylisobenzofuran: A useful intermediate for the construction of phenyl-substituted acenes
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(Chemical Equation Presented) The formation and subsequent reactivity of previously unknown 4,7-diphenylisobenzofuran, 5, is reported. The Diels-Alder reaction between 5 and p-benzoquinone in boiling glacial acetic acid yields an unprecedented exo,exo ant
- Rainbolt, James Eric,Miller, Glen P.
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p. 3020 - 3030
(2007/10/03)
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- Reaktivity of Substituted 1,3-Butadienes in Diels-Alder-Reactions
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Kinetic data for the reaction of substituted 1,3-dienes with tetracyanoethylene (TCNE) and other dienophiles are interpreted in terms of the FMO-model.While the expectations are fulfilled qualitatively, the kinetic data cannot be correlated quantitatively.This shows that in Diels-Alder reactions besides HOMO-LUMO separation other factors play an important role, for instance the 1,4-distance in the diene and the conformational equilibrium cisoid transoid of the diene.The kinetic data are in accord with a one-step mechanism of the cycloaddition reaction.
- Ruecker, Christa,Lang, Dietrich,Sauer, Juergen,Friege, Henning,Sustmann, Reiner
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p. 1663 - 1690
(2007/10/02)
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