- Augmenting Adaptive Machine Learning with Kinetic Modeling for Reaction Optimization
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We combine random sampling and active machine learning (ML) to optimize the synthesis of isomacroin, executing only 3% of all possible Friedl?nder reactions. Employing kinetic modeling, we augment machine intuition by extracting mechanistic knowledge and
- Almeida, A. Filipa,Ataíde, Filipe A. P.,Loureiro, Rui M. S.,Moreira, Rui,Rodrigues, Tiago
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- Novel farnesyl protein transferase inhibitors as antitumor agents
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Disclosed are novel tricyclic compounds represented by the formula (1.0): and a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising compounds of formula 1.0. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
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- Imidazolo-5-YL-2anilino-pyrimidines as agents for the inhibition of the cell proliffration
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Compounds of the formula (I): wherein R1, R2, R3, R4, R5, R6, p, q, and n are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti-cell-proliferation) effect in a warm-blooded animal, such as man.
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(2010/02/05)
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