209901-86-0

Two-photon active probe to label apoptotic cells plays a significant role in biological systems. However, discrimination of live/apoptotic cells at subcellular level under microscopy remains unachieved. Here, three novel Zn(II) terpyridine-based nitrate c

A novel ruthenium-terpyridine based photosensitizer, Ru[(p-F-tpy)(pcqH)Cl] PF6 (1); (p-F-tpy = 4′-(4-fluorophenyl)-2,2′:6′,2″-terpyridine, pcqH = 2-(2-pyridyl)-4-carboxyquinoline) was synthesized and spectroscopically characterized. The electro

Light-emitting materials are of significant interest owing to their potential applications in electroluminescent devices/displays and sensors. Herein, light-emitting metallogel systems are developed using self-assembled Ln(iii)-complexes (Ln(iii) = Eu(iii

Copper(II) complexes of the type [Cu(SPF)(Ln)Cl] (where SPF is sparfloxacin and Ln = substituted terpyridines) were synthesized and found to have a distorted octahedral geometry. Superoxide dismutase-like activity of the complexes wa

The drug-resistance of cancer cells has become a major obstacle to the development of clinical drugs for chemotherapy. In order to overcome cisplatin-resistance, seven cyclometalated ruthenium(ii) complexes were synthesized with a varying degree of fluorine substitution, for use as anticancer agents. A cytotoxicity assay testified that the complexes possessed a more cytotoxic effect than cisplatin towards the cisplatin-resistant cell line A549R. The number of fluorine atoms regulated the lipophilicity of the complexes, but the relationship was not linear.Ru1containing one fluorine atom had the highest lipophilicity and the best therapeutic effect. The complexes enter cells through an energy-dependent pathway and then localize in the nuclei and mitochondria. The complexes induced nuclear dysfunction by the inhibition of DNA replication as well as mitochondrial dysfunction by the loss of membrane potential. The damage to these vital organelles leads to cell apoptosisviathe caspase 3/7 pathway. Our results indicated that the modulation of the number of fluorine atoms in therapeutic agents can have a profound effect andRu1is a complex with a high potential as a drug for the treatment of cisplatin-resistant cancer.

A series of heterobimetallic wire-like organometallic complexes [(tpy-C6H4-R)(PPh3)2Ru-C-C-Fc]+ (tpy-C6H4-R = 4′-(aryl)-2,2′:6′,2′′-terpyridyl, Fc = [(η5-Cp)2Fe], R = -H, -Me, -F, -NMe2 in complexes 5-8, respectively) featuring ferrocenyl and 4′-(aryl)-2,2′:6′,2′′-terpyridyl ruthenium(II) complexes as redox active metal termini, have been synthesized. Various spectroscopic tools, such as multinuclear NMR, IR spectra, HRMS, CHN analyses, and single crystal X-ray crystallography have been utilized to characterize the heterobimetallic complexes. The electrochemical and UV-vis-NIR spectroscopic studies have been investigated to evaluate the electronic delocalization across the molecular backbones of the Ru(II)-Fe(II) heterobinuclear organometallic dyads. Electrochemical studies reveal two well-separated reversible redox waves as a result of successive oxidation of the ferrocenyl and Ru(II) redox centers. The spin density distribution analyses reveal that the initial oxidation process is associated with the Fe(II)/Fe(III) couple followed by one electron oxidation of the ruthenium(II) center. The high Kc value (0.11-1.73 × 1012) and intense NIR absorption, with molar absorption coefficient (in the order of 103 M-1 cm-1) for the RuIIFeIII mixed-valence species, signify strong electronic communication between the two metal termini. The electronic coupling constant (Hab) has been estimated to be 492 and 444 cm-1 for the structurally characterized complexes 6 and 7, respectively. The redox and NIR absorption features indicate that the mixed-valence system of the heterobinuclear dyads belongs to a Robin and Day "class II" system.

A series of cationic [Ru(L)(PPh3)2Cl]+ (1–3) and neutral [Ru(L)(PPh3)Cl2] (4–6) RuII complexes were synthesized by reacting [RuCl2(PPh3)2] with 4′-(aryl)-2,2′:6′,2′′-terpyridyl-based ligands (L1–L3) with various aryl groups (tolyl, phenyl and 4-fluorophenyl). The synthesized RuII complexes were unambiguously characterized by various spectroscopic techniques such as FTIR and multinuclear NMR spectroscopy as well as HRMS. The neutral complexes (4–6) were also structurally characterized by single-crystal X-ray diffraction studies. Photophysical and electrochemical studies of the RuII complexes were performed to elucidate the effects of the 4′-aryl substituents of L1–L3. These RuII complexes show good catalytic activities in the transfer hydrogenation (TH) of ketones with a wide substrates scope in 2-propanol under reflux. An optimization study revealed that the neutral RuII complexes are better catalysts than the cationic RuII complexes for TH reactions. Finally, [Ru(L1)(PPh3)2H]+ (7) with a [RuII–H] functionality was successfully synthesized and isolated and is proposed as the catalytically active species. A control experiment with the [RuII–H] complex in the absence of base was performed to establish the mechanism for the catalytic TH of ketones.

Mitochondria are the control centers of apoptosis. To study mitochondrial dynamics during apoptosis, four phosphorescent fluorinated iridium(iii) complexes (Ir1-Ir4) were designed and synthesized. The complexes' emission maxima, phosphorescent quantum yie

Direct functionalization of terpyridines is an increasingly important topic in the field of dyes and catalysis as well as supramolecular chemistry, but its synthesis and transformation is usually challenging. Herein, a HOMO-raising strategy is reported for the construction of a super-stable novel terpyridine chromophores, in which the selective oxidation of terpyridines at its 3-position was determined successfully to the synthesis of phenol-functionalization of terpyridines (TPyOHs) bearing a hydrogen bonding group. The corresponding TPyOHs displayed strong aggregation-induced emission and exhibited highly selective and visual detection of ZnII cation with a record green terpyridine-based luminophore with nanomolar sensitivity (125 nm).

An octahedral complexes of copper with clioquinol(CQ) and substituted terpyridine have been synthesized. The Cu(II) complexes have been characterized by elemental analyses, thermogravimetric analyses, magnetic moment measurements, FT-IR, electronic,

The novel octahedral copper(II) complexes with the second generation fluoroquinolone, norfloxacin and terpyridine derivatives were prepared and characterized. The antimicrobial efficiency of the complexes were tested on five different microorganisms and s

A clean aqueous Kr?hnke reaction process has been accomplished via a one-pot procedure of 2-acetylpyridine with aromatic aldehyde and ammonium acetate under microwave irradiation or conventional heating conditions. This method is convenient, economic and environmental friendly.

A series of 4′-aryl-2,2′:6′,2″-terpyridines have been prepared by the one-pot reaction of 2-acetylpyridine with aromatic aldehydes in the presence of ammonium acetate under microwave irradiation. This method has the advantages of shorter route, easier workup, shorter reaction time, higher yield and more environmentally friendly conditions, compared to the conventional ones. Georg Thieme Verlag Stuttgart.