- NOVEL POLYMORPHS OF GEMIFLOXACIN MESYLATE
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The present invention provides novel crystalline sesquihydrate form 1, sesquihydrate form 2, anhydrous form 3 and anhydrous form 4 of gemifloxacin mesylate, processes for their preparation and pharmaceutical compositions containing them. The present inven
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Page/Page column 16
(2010/12/31)
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- AN IMPROVED PROCESS FOR THE PREPARATION OF GEMIFLOXACIN MESYLATE
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The present invention relates to an improved process for the preparation of Gemifloxacin mesylate of formula (V). The present invention further provides novel intermediates of formula (II) and (IV), which are useful intermediates for the preparation of Gemifloxacin mesylate of formula (V) wherein R1 is linear or branched chain alkyl group having 1-3 carbon atoms.
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Page/Page column 12
(2008/12/05)
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- Process for the production of a naphthyridine carboxylic acid derivative (methanesulfonate sesquihydrate)
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A process for the production of a naphthyridine carboxylic acid derivative having antibacterial activity.
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Page column 2-3
(2008/06/13)
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- NEW PROCESS FOR PREPARING 4-AMINOMETHYL-3-ALKOXYIMINOPYRROLIDINE METHANESULFONATE
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The present invention relates to a process for the preparation of 4-aminomethyl-3-alkoxyiminopyrrolidine methanesulfonate, a key intermediate of quinolone antibiotics. According to the process of the present invention, the total number of steps has been shortened to 2-3 steps, the solid separation is not required, and the use of costly chemicals, particularly (BOC)2O (t-butoxycarbonyl anhydride), several organic solvents and reactants, is eliminated.
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- Intermediates for the production of quinolone carboxylic acid derivatives
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Chemical intermediates which are of use in the production of quinolone carboxylic acid derivatives having antibacterial activity.
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Page column 5
(2010/02/05)
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- PROCESS FOR PREPARING ACID SALTS OF GEMIFLOXACIN
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The present invention relates to a process for preparing acid salts of Gemifloxacin, a quinolone type antibiotic agent having potent antimicrobial activity. The process according to the present invention can provide advantages such as simplicity of proces
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Page/Page column 13-14
(2008/06/13)
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- Salt of naphthyridine carboxylic acid derivative
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7-(3 -Aminomethyl-4-methoxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate and hydrates thereof, processes for their preparation, pharmaceutical compositions comprising them, and their use in antibacterial therapy.
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- 7-(4-aminomethyl-3-methyloxyiminopyrroplidin-1-yl)-1-cyclopropyl-6-flu oro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid and the process for the preparation thereof
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The present invention relates to a novel quinolone compound having an excellent antibacterial activity. More specifically, the present invention relates to 7-(4-aminomethyl-3-methyloxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1, 4-dihydro-1,8-nap
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