- The cytotoxic effects of diketopiperaizes against Leishmania donovani promastigotes and amastigotes
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A series of diketopiperazine derivatives (1-12) were evaluated for their in vitro cytotoxic activity against Leishmania donovani promastigotes and amastigotes. Cytotoxicity study revealed that the number and types of the substituents in the phenyl rings h
- Maity, Arindam,Hazra, Abhijit,Palit, Partha,Mondal, Shymal,Lala, Sanchaita,Mondal, Nirup B.
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p. 3452 - 3458
(2013/07/19)
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- Efficient synthesis of piperazinediones using potassium iodide catalysis in aqueous media
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A simple and efficient synthetic approach to 1,4-disubstituted piperazine-2,5-diones was developed. A series of symmetrical 1,4-disubstituted piperazine-2,5-diones was prepared from chloroacetamides using potassium iodide catalysis in acetone/water. The structures of two products were confirmed by single crystal X-ray diffraction analysis.
- Wen, Yong-Hong,Chen, Xiao-Na,Wen, Hui-Ling,Tang, Xiao-Fang
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experimental part
p. 732 - 736
(2012/06/01)
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- Synthesis of 1,4-diaryl-piperazine-2,5-diones: New behavior of N,N-dimethylformamide dimethyl acetal (DMFDMA)
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Reactions of chloroacetamides (5) with N,N-dimethylformamide dimethyl acetal gave 1,4-diaryl-piperazine-2,5-diones 11a-e in good yield, rather than 1,5-diaryl-3,7-dimethoxy-1H,5H-[1,5]diazocine-2,6-diones (9a-e). Copyright Taylor & Francis Group, LLC.
- Abu-Shanab, Fathi A.,Al-Harrasi, Ahmed,Mousa, Sayed A. S.
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p. 376 - 382
(2008/04/01)
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- Synthesis of symmetrically 1,4-disubstituted piperazine-2,5-diones: A new class of antileishmanial agents
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A series of 1,4-diphenyl-2,5-dioxopiperazine derivatives were synthesised in one pot sequence. The compounds demonstrated appreciable cytotoxic activity against Leishmania donovani on both forms of the parasite, and the results suggested that some derivat
- Hazra, Abhijit,Paira, Priyankar,Palit, Partha,Banerjee, Sukdeb,Mondal, Nirup B.,Sahu, Niranjan P.
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p. 381 - 383
(2008/02/11)
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- Synthesis of Novel Imidazole-Containing DNA Minor Groove Binding Oligopeptides Related to the Antiviral Antibiotic Netropsin
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Analysis of the structural and stereochemical requirements for the strict DNA base sequence recognition of (AT)4 and (AT)5 respectively for the oligopeptide minor groove binding agents netropsin and distamycin leads to proposals for the rational structure
- Krowicki, Krzysztof,Lown, J. William
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p. 3493 - 3501
(2007/10/02)
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