- Alkylation of Aromatic Amines with Trialkyl Amines Catalyzed by a Defined Iridium Complex with a 2-Hydroxypyridylmethylene Fragment
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Six Cp?Ir complexes containing NN-bitentate chelate ligands [Cp?IrCl(C5H4CH2C5H3OH)][Cl] (1), [Cp?IrCl(C5H4CH2C5H3O)] (2), [Cp?IrCl(C5H4C5H3OH)] [Cl] (3), [Cp?IrCl(C5H4CH2C5H4)][Cl] (4), [Cp?IrCl(CH3OC5H3CH2C5H3OCH3)][Cl] (5), and [Cp?IrCl(CH3OC5H3CH2C5H3OH)][Cl] (6) were synthesized and characterized. Complex 1 could be transformed to 2 when reacted with NaOtBu or NEt3 via -OH deprotonation. These six complexes were tested as catalysts for mono-N-alkylation of amines with trialkyl amines, and complex 1 exhibited highest activity. The coupling reactions proceed under air condition, with 1 mol % catalyst loading without extra base in methanol at 120 °C and can be further accelerated by adding NR3·HCl.
- Deng, Danfeng,Hu, Bowen,Zhang, Ziyu,Mo, Shengkai,Yang, Min,Chen, Dafa
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p. 2218 - 2226
(2019/05/21)
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- Microwave assisted one pot synthesis of 2-ethylamino benzimidazole, benzoxazole and benzothiazole derivatives
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A rapid and efficient one-pot method for the synthesis of 2-ethylamino benzimidazole, benzoxazole, and benzothiazole derivatives has been described. The reaction of o-phenylenediamines or o-aminophenols or 2-mercaptoanilines with EDC.HCl under microwave irradiation afforded the corresponding 2-ethylamino benzimidazole, benzoxazole and benzothiazole derivatives in excellent yields.
- Rapolu, Thirupathi,K. V. P, Pavan Kumar,Babu, Korupolu Raghu,Dende, Satheesh Kumar,Nimmareddy, Rajashekar Reddy,Reddy, Leleti Krishnakanth
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supporting information
p. 1308 - 1315
(2019/04/30)
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- Iron-catalyzed direct amination of azoles using formamides or amines as nitrogen sources in air
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A new iron-catalyzed, direct C-H amination of azoles at C2 has been developed by using formamides or amines as nitrogen sources. Imidazole is the only additive in the catalyst system and oxygen in air is employed during the transformation process.
- Wang, Jian,Hou, Ji-Ting,Wen, Jun,Zhang, Ji,Yu, Xiao-Qi
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supporting information; experimental part
p. 3652 - 3654
(2011/05/02)
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