- Rhodium-Catalyzed Ring-Opening Hydroacylation of Alkylidenecyclopropanes with Chelating Aldehydes for the Synthesis of γ,δ-Unsaturated Ketones
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The first intermolecular ring-opening hydroacylation of alkylidenecyclopropanes with chelating aldehydes through a rhodium-catalyzed acrylamide-promoted protocol is reported. This highly efficient catalytic system enables the direct synthesis of a diverse
- Li, Hong-Shuang,Lu, Shi-Chao,Chang, Zhi-Xin,Hao, Liqiang,Li, Fu-Rong,Xia, Chengcai
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- Cobalt(iii)-catalyzed redox-neutral [4+2]-annulation ofN-chlorobenzamides/acrylamides with alkylidenecyclopropanes at room temperature
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An efficient synthesis of substituted 3,4-dihydroisoquinolinones through [4+2]-annulation ofN-chlorobenzamides/acrylamides having a monodentate directing group with alkylidenecyclopropanes in the presence of a less expensive, highly abundant and air stable Co(iii) catalystviaa C-H activation is demonstrated. In this reaction, the N-Cl bond ofN-chlorobenzamide serves as an internal oxidant and thus an external metal oxidant is avoided. The 3,4-dihydroisoquinolinone derivatives are converted successfully into the highly useful imidoyl chloride derivatives. The deuterium labeling and kinetic isolabelling studies reveal that the C-H activation is a rate-determining step in this cyclization reaction.
- Ramesh, Balu,Jeganmohan, Masilamani
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supporting information
p. 3692 - 3695
(2021/04/16)
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- Gem-Difluorination of Methylenecyclopropanes (MCPs) Featuring a Wagner-Meerwein Rearrangement: Synthesis of 2-Arylsubstituted gem-Difluorocyclobutanes
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The geminal difluorocyclobutane core is a valuable structural element in medicinal chemistry. Strategies for gem-difluorocyclobutanes, especially the 2-substituted cases, are limiting and often suffer from harsh reaction conditions. Reported herein is a m
- Lin, Peng-Peng,Huang, Long-Ling,Feng, Si-Xin,Yang, Shuang,Wang, Honggen,Huang, Zhi-Shu,Li, Qingjiang
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supporting information
p. 3088 - 3093
(2021/05/05)
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- Visible-Light-Catalyzed C-C Bond Difunctionalization of Methylenecyclopropanes with Sulfonyl Chlorides for the Synthesis of 3-Sulfonyl-1,2-dihydronaphthalenes
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A novel visible-light-catalyzed sulfonylation/arylation of carbon-carbon σ-bond with sulfonyl chlorides for the synthesis of 3-sulfonylated 1,2-dihydronaphthalenes is developed. This difunctionalization proceeds via a sequence of C=C bond sulfonylation, C-C σ-bond cleavage, and intramolecular cyclization, and the experiment result shows that the C-C σ-bond difunctionalization reaction includes a radical process. This strategy provides a simple and convenient route for difunctionalization of C-C bonds with an aromatic carbon and a sulfonyl radical by one-pot construction of a C-S bond and a new C-C bond.
- Liu, Yu,Wang, Qiao-Lin,Chen, Zan,Zhou, Quan,Li, Hua,Zhou, Cong-Shan,Xiong, Bi-Quan,Zhang, Pan-Liang,Tang, Ke-Wen
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p. 2829 - 2839
(2019/03/07)
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- Transition Metal-Free Difunctionalization of C?C Bond with Sodium Sulfinates and Water Leading to (E)-1-Phenyl-4-sulfonylbut-1-enes
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Without using any transitionmetal and base, an eco-friendly, practical and economical protocol has been established for the one-pot synthesis of diverse (E)-1-phenyl-4-sulfonylbut-1-enes from easily accessible starting materials. This strategy features a wide substrate scope, tolerates a broad range of functional groups, employs a less expensive oxidant, is operationally simple, and can be easily scaled-up. (Figure presented.).
- Wang, Qiao-Lin,Chen, Zan,Zhou, Quan,Zhou, Cong-Shan,Xiong, Bi-Quan,Zhang, Pan-Liang,Yang, Chang-An,Liu, Yu,Tang, Ke-Wen
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supporting information
p. 2315 - 2320
(2019/04/13)
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- Copper(I)-Catalyzed Intramolecular Trifluoromethylation of Methylenecyclopropanes
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Copper(I)-catalyzed intramolecular trifluoromethylation of methylenecyclopropanes has been developed to produce a variety of CF3-substituted dihydronaphthalenes in moderate to good yields, relying on the construction of C(sp2)-CFsub
- Zhu, Zi-Zhong,Chen, Kai,Yu, Liu-Zhu,Tang, Xiang-Ying,Shi, Min
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supporting information
p. 5994 - 5997
(2016/01/09)
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- 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES
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Compounds of the formula (I), in which the substituents are as defined in claim 1, are suitable for use as nematicides.
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Page/Page column 83
(2015/02/02)
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- N-Cyclylamides as nematicides
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Compounds of the formula in which the substituents are as defined in claim 1, are suitable for use as nematicides.
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Paragraph 0133
(2013/10/21)
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- N-CYCLYLAMIDES AS NEMATICIDES
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Compounds of the formula (I), in which the substituents are as defined in claim 1,are suitable for use as nematicides.
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Page/Page column 79
(2013/10/21)
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- Synthesis of benzylidenecyclopropanes from γ-halopropyl pentachlorophenyl sulfones using a Julia-Kocienski olefination
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Simple, one-step synthesis of benzylidenecyclopropanes from γ-halopropyl pentachlorophenyl sulfones using a Julia-Kocienski olefination is reported. Georg Thieme Verlag Stuttgart.
- Ma?kosza, Mieczys?aw,Bujok, Robert
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p. 586 - 588
(2008/12/22)
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