- Oxiranes with quinolone substitution: Stereoselective synthesis and antiviral activity
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A series of new quinoline substituted oxiranes were synthesized by the reaction of 2-N-(chloroacetyl)-1-(4'-methyl-2'-quinolinyl) hydrazine and aromatic aldehydes. These compounds were tested against encephalomyocarditis virus (EMVC) and only two compounds exhibited protection against the virus.
- Kidwai,Kumar,Goel,Srivastava
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- CONDENSED RING PYRIDINE COMPOUNDS AS SUBTYPE-SELECTIVE MODULATORS OF SPHINGOSINE-1-PHOSPHATE-2 (S1P2) RECEPTORS
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The invention provides compounds represented by the formula I, each of which compounds may have sphingosine-1-phosphate receptor agonist and or antagonist biological activity, wherein these compounds selected from the group consisting of wherein A, B, C, D, X, Y, Z and R3 are defined in the specification. Said compounds are useful for treating a disease or condition of a mammal selected from the group consisting of ocular diseases; systemic vascular barrier related diseases; allergies and other inflammatory diseases; cardiac diseases or conditions; fibrosis; pain and wounds.
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(2011/04/25)
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- NOVEL FUSED TRIAZOLONES AND THE USES THEREOF
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This invention relates to novel compounds having the structural diagram (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.
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