- Reduced Phenalenyl in Catalytic Dehalogenative Deuteration and Hydrodehalogenation of Aryl Halides
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Dehalogenative deuteration reactions are generally performed through metal-mediated processes. This report demonstrates a mild protocol for hydrodehalogenation and dehalogenative deuteration of aryl/heteroaryl halides (39 examples) using a reduced odd alternant hydrocarbon phenalenyl under transition metal-free conditions and has been employed successfully for the incorporation of deuterium in various biologically active compounds. The combined approach of experimental and theoretical studies revealed a single electron transfer-based mechanism.
- Singh, Bhagat,Ahmed, Jasimuddin,Biswas, Amit,Paira, Rupankar,Mandal, Swadhin K.
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p. 7242 - 7255
(2021/05/29)
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- Method for synthesizing alkyl-2-naphthyl ether
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The invention discloses a method for synthesizing alkyl-2-naphthyl ether. 2-naphthol, a catalyst and dialkyl carbonate are heated to 110-120 DEG C, dialkyl carbonate is added dropwise, a mixed solution of dialkyl carbonate and corresponding alcohol is fractionated out during dropwise addition, the temperature is controlled not to exceed 200 DEG C, reaction is stopped when conversion of 2-naphtholreaches 95% or higher, inorganic boric acid and a dehydration solvent are added, unreacted 2-naphthol is removed, and rectification or recrystallization is performed, and a pure product is obtained. The process route has little corrosion to equipment, few 'three wastes' emissions and low environmental pollution.
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Paragraph 0018
(2019/01/14)
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- Methylation of arenes via Ni-catalyzed aryl C-O/F activation
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Aryl C-O and C-F can be transformed into C-Me via Ni-catalyzed coupling with MeMgBr under mild conditions. The Royal Society of Chemistry.
- Guan, Bing-Tao,Xiang, Shi-Kai,Wu, Tao,Sun, Zuo-Peng,Wang, Bi-Qin,Zhao, Ke-Qing,Shi, Zhang-Jie
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p. 1437 - 1439
(2008/12/21)
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