- Solubilization of dipropofol, an antibacterial agent, using saccharide and ascorbic acid
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Dipropofol has a strong antibacterial activity against Gram-positive bacteria. However, it lacked the solubility in water and this property was supposed to limit its efficacy. We tried to improve the solubility and found a new solubilization method of dipropofol in water by the addition of a monosaccharide or ascorbic acid.
- Ogata, Masahiro,Oka,Seki, Masako,Hoshi, Midori,Takatsu, Hirokatsu,Mashino, Tadahiko,Urano, Shiro,Endo, Toyoshige
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- A green mesostructured vanadosilicate catalyst and its unprecedented catalytic activity for the selective synthesis of 2,6-disubstituted p-benzoquinones
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We have developed a green method for the production of 2,6-disubstituted p-benzoquinones (DSBQs) by liquid-phase oxidations of di/tri-substituted phenols using two-dimensional hexagonally thick-walled mesoporous vanadosilicate catalysts. In particular, 2,6-di-tert-butyl-p-benzoquinone was synthesized by the oxidation of 2,6-di-tert-butylphenol, using various reaction parameters, over mesoporous VSBA-15 catalysts synthesized with various vanadium contents. A promising chemical treatment method for the preparation of green mesoporous VSBA-15(5) or W-VSBA-15(5) (W: washed) catalysts was successfully used in the presence of ammonium acetate solution to remove moderately toxic non-framework V2O5 crystallite species from the active surface, and the catalytic activity of the recovered green mesoporous VSBA-15(5) catalyst was determined. To confirm the green aspects, recyclability and hot-catalytic filtration experiments were performed. The combined results show that the green mesoporous VSBA-15(5) is a highly active, recyclable, and promising heterogeneous catalyst for the selective synthesis of DSBQs (98-100%), and has unprecedented catalytic activity compared with other mesoporous vanadosilicate catalysts. The Royal Society of Chemistry 2014.
- Selvaraj,Park,Kim
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p. 958 - 966
(2014/01/06)
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- Oxidative coupling of some 2,6-disubstituted phenol derivatives in perchloric acid mediated by cerium(IV) ions
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2,6-Disubstituted phenol derivatives have been oxidized by cerium(IV) perchlorate in aqueous or aqueous-acetonitrile solutions of perchloric acid as well as in two-phase systems to the corresponding 1,4-benzoquinones, 4,4′-diphenoquinones, and oligomeric
- Domagala, Slawomir,Steglinska, Violetta,Dziegiec, Jozef
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p. 761 - 768
(2007/10/03)
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- Choice of Manganese(III) Complexes for the Synthesis of 4,4'-Biphenyldiols and 4,4'-Diphenoquinones
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2,6-Disubstituted phenols are oxidized with tris(2,4-pentanedionato)manganese(III), , in glacial acetic acid to give the corresponding 4,4'-biphenyldiols in high yields, whereas similar reactions using manganase(III) acetate, , instead of quantitatively yield the corresponding 4,4'-diphenoquinones.Cross-coupling reactions of 2,6-di-t-butylphenol and other substituted phenols afford the corresponding cross-coupled 4,4'-biphenyldiols and 4,4'-diphenoquinones together with oxidation products derived from them starting phenols themselves.The advantageous use of and Mn(OAc)3> in the ubiqitous phenol coupling reaction is discussed.
- Nishino, Hiroshi,Nobuyuki, Itoh,Nagashima, Makiko,Kurosawa, Kazu
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p. 620 - 622
(2007/10/02)
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- Mushroom tyrosinase catalysed coupling of hindered phenols: A novel approach for the synthesis of diphenoquinones and bisphenols
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An efficient oxidative carbon-carbon coupling of hindered phenols leading to diphenoquinones and bisphenols by mushroom tyrosinase is reported.
- Pandey,Muralikrishna,Bhalerao
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p. 3771 - 3774
(2007/10/02)
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