Synthesis and characterization of new aromatic hydroxy acid compounds
Four novel aromatic hydroxy acid (HA) compounds N-(4-hydroxyphenyl)-4’-trimellitimide, N-(3-hydroxyphenyl)-4’-trimellitimide, N-(5-hydroxynaphthyl)-4’-trimellitimide and N-{4’-[2-(4-hydroxyphenyl) isopropyl phenyl]}-4’’-trimellitimide are synthesized thro
Thiruvasagam
p. 523 - 530
(2018/12/13)
Design, synthesis, and structure-activity relationships of phthalimide- phenylpiperazines: A novel series of potent and selective {1a)-adrenergic receptor antagonists
Beginning from the screening hit and literature α1-adrenergic compounds, a hybridized basic skeleton A was proposed as the pharmacophore for potent and selective α(1a)-AR antagonists. Introduction of a hydroxy group to increase the flexibility