- Efficient photodecarboxylation of aroyl-substituted phenylacetic acids in aqueous solution: A general photochemical reaction
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Photolysis (254-350 nm) of a variety of aroyl-substituted phenylacetic acids and p-acetylphenylacetic acid in aqueous solution at pH > pK(a) resulted in efficient photodecarboxylation (Φ = 0.2-0.7), to give in most cases a single product arising via the corresponding arylmethyl carbanion, indicating that photodecarboxylation is an efficient and general reaction for these types of compounds.
- Xu,Wan
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p. 2147 - 2148
(2007/10/03)
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- Hydroxyquinolone derivatives compounds which have pharmaceutical utility
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This present invention relates to a class of 4-hydroxy-2-(1H)-quinolones which are substituted in the 3-position by an optionally substituted aryl substituent. These compounds are selective non-competitive antagonists of N-methyl-D-aspartate (NMDA) receptors.
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- Esters and amides of substituted phenyl acetic acids
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Esters and amides of substituted phenyl acetic acids having the formula wherein Q is a deprotonated residue of a polymer or macromolecular structure having a molecular weight of at least 1000 containing at least two primary and/or secondary amino groups and/or hydroxy groups;, n is an integer of at least 2;, R1 and R2 are independently selected from, hydrogen, halogen, alkyl, alkenyl, alkinyl or halo alkyl;, R3 is one or more substituents selected from halogen, alkyl, alkenyl or alkinyl, cycloalkyl, oxo-substituted alkylcycloalkyl, haloalkyl, alkoxy, alkenyloxy, alkinyloxy, alkylamino, alkenylamino, alkinylamino, alkysulfonyl, alkenylsulfonyl, alkinylsulfonyl, alkylsulfinyl, alkenylsulfinyl, alkinylsulfinyl, alkylsulfenyl, alkenylsulfenyl, alkinylsulfenyl, pyrrolyl, piperidinyl, benzoyl, imidazolpyridinyl, isoindolyl, oxo-substituted isoindolyl, thionylcarbonyl, phenyl, phenoxy and halo-substituted phenoxy, are useful in the treatment of colonic polyps.
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- REMOTE FUNCTIONALIZATION ON THE STEROID β-FACE: ATTACK ON CARBON-15
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6β-(3'-Benzoylphenyl)acetoxy group is a good template for selective functionalization of carbon-15 of steroids.
- Lee, Eun,Lee, Hyeon Ho,Chang, Hye Kyung,Lim, Dong Yeol
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p. 339 - 342
(2007/10/02)
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- ARENES FROM ALKANES OR CYCLOALKANES THROUGH DEHYDRATION OR REARRANGEMENT WITH PYRIDINIUM CHLORIDE
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The preparations of various kinds of arylacetic acids both from the precursors and from the synthetic equivalents of (2-oxocyclohexenyl)acetic acids are reviewed.Particular attention is paid to the methods by which these intermediates can be obtained since the usefulness of the reaction is obviously bound to substrate availability.Further developments in the field of aromatic hydrocarbons and heterocyclic compounds are illustrated and a model for the reaction is proposed.In addition to the data already published in scientific journals and in the patent literature, several unpublished data are reported.
- Baiocchi, Leandro,Giannangeli, Marilena,Bonanomi, Michele,Picconi, Giuseppe,Ridolfi, Pietro
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p. 199 - 216
(2007/10/02)
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- Bulky amine analogues of ketoprofen: Potent antiinflammatory agents
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Replacement of the carboxyl group of 2-(3-benzoylphenyl)propionic acid (Ketoprofen) with various bulky amines has produced a series of highly active antiinflammatory agents that have reduced intestinal ulcerogenicity and have better therapeutic ratios in the 21-day adjuvant arthritis assay on rats than currently marketed nonsteroidal antiinflammatory drugs. Activity is maintained on reduction of these 2-(3-benzoylphenyl)propyl bulky amines to the corresponding alcohols or methylene analogues, on conversion of the ketone function to a primary amine or oxime, and on introduction of a 4-halo substituent (Cl or F) on the terminal aromatic ring. Removal of the α-CH3 group greatly reduces the antiinflammatory activity of the series. These compounds have been synthesized by the reductive amination of 2-(3-bromophenyl)propionaldehyde with the respective amine followed by lithiation of this product and condensation with the appropriate benzonitrile.
- Schlegel,Zenitz,Fellows,Laskowski,Behn,Phillips,Botton,Speight
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p. 1682 - 1690
(2007/10/02)
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- Benzoylphenylacetic acid derivatives with antiinflammatory and analgesic activities
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Several derivatives of m benzoylphenylacetic acid showed interesting antiinflammatory and analgesic properties associated with good gastric tolerance.
- Allais,Rousseau,Meier,et al.
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p. 381 - 389
(2007/10/06)
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