- Hydrogen Bond Donor Catalyzed Cationic Polymerization of Vinyl Ethers
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The synthesis of high-molecular-weight poly(vinyl ethers) under mild conditions is a significant challenge, since cationic polymerization reactions are highly sensitive to chain-transfer and termination events. We identified a novel and highly effective h
- Kottisch, Veronika,Jermaks, Janis,Mak, Joe-Yee,Woltornist, Ryan A.,Lambert, Tristan H.,Fors, Brett P.
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Read Online
- Thiophosphate and thiophosphonate analogues of glucose-1-phosphate: Synthesis and enzymatic activity with a thymidylyltransferase
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Synthetic methods were investigated for the preparation of O and S-glucosyl thiophosphates and glucosyl 1C-thiophosphonate. Four protected glucosyl thiophosphate compounds were synthesized and characterized as precursors to glucose 1-thiophosphate. The ef
- Loranger, Matthew W.,Beaton, Stephen A.,Lines, Katie L.,Jakeman, David L.
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Read Online
- Synthesis and cholinesterase inhibitory activity of n-phosphorylated / n-tiophosphorylated tacrine
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Background: Alzheimer’s disease (AD) is progressive and irreversible neurodegenera-tive disorder. Current pharmacotherapy is not able to stop progression of the disease and can only improve cognitive functions. Therefore, new drugs are being sought that w
- Demkowicz, Sebastian,Dzierzbicka, Krystyna,Inkielewicz-Stepniak, Iwona,Kowalski, Szymon,Da?ko, Mateusz,Przyby?owska, Maja
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p. 947 - 957
(2020/08/19)
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- Curcumin phosphate compound, preparation method and uses thereof
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The present invention relates to a curcumin phosphate compound, a preparation method and uses thereof, and belongs to the field of pharmaceutical chemistry, wherein the structural general formula of the compound is defined in the specification, X is O or
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Paragraph 0129; 0130; 0131
(2016/10/08)
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- A simple and efficient approach to the synthesis of 1-phosphonated 5-amino-1-H-[1,2,4]-triazole from N-functionalized imidates
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In this study, we describe a new and easy synthetic approach to variously substituted triazoles based on the reaction of imidates with phosphorylated hydrazine in good yields. A general mechanism of the reactions was also proposed. Characterization of the products was carried out by several analytical and spectroscopic tools including infrared and nuclear magnetic resonance spectroscopies (1H,13C NMR,31P NMR).
- Jabli, Dhiab,Dridi, Khaireddine,Efrit, Mohamed Lotfi
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p. 759 - 764
(2016/05/09)
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- Design and synthesis of novel active phosphonate esters and their application in preparation of ceftriaxone
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For a series of active phosphonate esters, the anhydride abbreviated as ANPTA (6a) exhibits the highest reactivity in the preparation of ceftriaxone. The synthesis of ceftriaxone was optimized with the pilot-scale yield reaching 95.7%. The results were explained from the structural viewpoint and supported by analysis of the calculated Mulliken atomic charge distribution.
- Ren, Hui-Xue,Sun, You-Min,Wu, Dao-Ji,Ma, Yong-Shan,Ying, Han-Jie,Ma, Yan
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p. 155 - 159
(2014/07/07)
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- Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: A structure-activity study
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We recently reported the anti-cancer and anti-cytomegalovirus (CMV) activity of artemisinin-derived trioxane diphenylphosphate dimer 838. To probe the relationship between chemical structure and anti-CMV and anti-cancer activities, we now report synthesis and evaluation of a series of eight new dimer phosphate ester analogs of 838. This series of novel molecules was screened against human foreskin fibroblasts (HFFs) infected with CMV and against the human Jurkat T cell acute lymphoblastic leukemia cell line. This SAR study confirms the very high anti-CMV and anti-cancer potencies of dimer diphenyl phosphate ester 838 without its being toxic to normal cells.
- Mott, Bryan T.,He, Ran,Chen, Xiaochun,Fox, Jennifer M.,Civin, Curt I.,Arav-Boger, Ravit,Posner, Gary H.
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p. 3702 - 3707
(2013/07/27)
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- Thiophosphoramide-based cooperative catalysts for Bronsted acid promoted ionic diels-alder reactions
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Three's a crowd: The combination of a Bronsted acid and a hydrogen-bond donor cocatalyst was found to promote various ionic [2+4] cycloadditions under mild reaction conditions (see scheme; Ts=4-toluenesulfonyl) . Thiophosphoramides are the most effective cocatalysts because of the stronger counterion activation effect resulting from three, rather than two, hydrogen bonds involved in anion binding.
- Borovika, Alina,Tang, Pui-In,Klapman, Seth,Nagorny, Pavel
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supporting information
p. 13424 - 13428
(2014/01/06)
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- A new strategy for the synthesis of pyridine amides, phosphorylated quinoline amides and their thio-analogues
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A new strategy for the synthesis of pyridine amides, phosphorylated quinoline amides and their thio-analogues has been developed. The direct reaction between in situ generated mixed phosphoric-carboxylic anhydrides with primary amines allowed a simultaneo
- Nycz
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experimental part
p. 1637 - 1642
(2010/07/08)
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- Kinetics and mechanism of the aminolysis of aryl phenyl chlorothiophosphates with anilines
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(Chemical Equation Presented) Kinetic studies of the reactions of aryl phenyl chlorothiophosphates (1) and aryl 4-chlorophenyl chlorothiophosphates (2) with substituted anilines in acetonitrile at 55.0°C are reported. The negative values of the cross-interaction constant ρXY (ρXY = -0.22 and -0.50 for 1 and 2, respectively) between substituents in the nucleophile (X) and substrate (Y) indicate that the reactions proceed by concerted SN2 mechanism. The primary kinetic isotope effects (kH/kD = 1.11-1.13 and 1.10-1.46 for 1 and 2, respectively) involving deuterated aniline nucleophiles are obtained. Front- and back-side nucleophilic attack on the substrates is proposed mainly on the basis of the primary kinetic isotope effects. A hydrogen-bonded, four-center-type transition state is suggested for a front-side attack, while the trigonal bipyramidal pentacoordinate transition state is suggested for a back-side attack. The MO theoretical calculations of the model reactions of dimethyl chlorothiophosphate (1′) and dimethyl chlorophosphate (3′) with ammonia are carried out. Considering the specific solvation effect, the front-side nucleophilic attack can occur competitively with the back-side attack in the reaction of 1′.
- Ul Hoque, Md. Ehtesham,Dey, Shuchismita,Guha, Arun Kanti,Chan, Kyung Kim,Lee, Bon-Su,Hai, Whang Lee
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p. 5493 - 5499
(2008/02/09)
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- Asymmetric addition of diethylzinc to diphenylphosphinoyl-imines catalyzed by copper(II) trifluoromethanesulfonate-chiral (2′-ethylamino-[1,1′] binaphthalenyl-2-yl)-thiophosphoramidic acid O,O′-diaryl ester ligands
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The chiral binaphthylthiophosphoramide L1 prepared from the reaction of O,O-diphenyl chlorothiophosphate with (R)-(+)-N-ethyl-1,1′-binaphthyl-2, 2′-diamine was used as a catalytic chiral ligand in the copper(II) trifluoromethanesulfonate-promoted asymmetr
- Shi, Min,Lei, Zhi-Yu,Xu, Qin
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p. 2237 - 2242
(2007/10/03)
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- The synthesis and evalution of novel aryl-substituted dithioimidophosphonates as an extrantant for metals
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A novel series of O,O′,O″,O?- tetraaryldithioimidophonates [(ArO)2PS]2NH 4 were synthesized by the reaction of O,O,-diaryl phosphorochlorothionates 2 and diarylphosphonothioic amide under a strong basic condition. The key intermediat
- Tang, Ruiren,Gou, Cancheng
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p. 2725 - 2731
(2007/10/03)
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- Phase-Transfer Reactions of Phosphorus Thiochloride with Phenols in the System Liquid-Solid Phase
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Preparative syntheses of aryl phosphorodichloridothioates and 2-propynyl phosphorodichloridothioates via phase-transfer reactions of phosphorus thiochloride with phenols in the presence of solid bases were developed.
- Shipov,Genkina,Mastryukova,Kabachnik
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p. 1345 - 1348
(2007/10/03)
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- SYNTHESIS OF O-ARYL DICHLOROTHIOPHOSPHATES VIA PHASE-TRANSFER CATALYSIS
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A convenient general method for synthesis of aryl dichlorothiophosphates via phase-transfer catalysis was developed.An influence of the reaction conditions on the yields and purity of the compounds synthesized was studied.
- Shipov, A. E.,Genkina, G. K.,Mastryukova, T. A.,Kabachnik, M. I.
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p. 1196 - 1200
(2007/10/02)
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