The invention provides novel tricyclic compounds of Formula (I) that inhibit B-secretase cleavage of APP and are useful as therapeutic agents for treating neurodegenerative diseases.
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Page/Page column 43-44
(2011/11/01)
Carboxy-substituted cinnamides: A novel series of potent, orally active LTB4 receptor antagonists
A series of carboxy-substituted cinnamides were investigated as antagonists of the human cell surface leukotriene B4 (LTB4) receptor. Binding was determined through measurement of [3H]-LTB4 displacement from hum
Greenspan, Paul D.,Fujimoto, Roger A.,Marshall, Paul J.,Raychaudhuri, Anil,Lipson, Kenneth E.,Zhou, Huanghai,Doti, Robert A.,Coppa, David E.,Zhu, Lijuan,Pelletier, Roberta,Uziel-Fusi, Susan,Jackson, Robert H.,Chin, Michael H.,Kotyuk, Bernard L.,Fitt, John J.
p. 164 - 172
(2007/10/03)
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