- STAT INHIBITORY COMPOUNDS AND COMPOSITIONS
-
Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for the inhibition of Signal Transducer and Activator of Transcription 5a and 5b (STAT5). Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as, for example, breast cancer, hematological cancer, and pancreatic cancer.
- -
-
Paragraph 0366; 0370
(2022/03/22)
-
- Memory of chirality approach to the enantiodivergent synthesis of chiral benzo[ d ]sultams
-
The "memory of chirality" stereodivergent synthesis of polyfluorobenzo[d]sultams has been developed. The interest of this protocol resides in the possibility of using the chirality of a starting sulfonamide single enantiomer to synthesize the target sulta
- Foschi, Francesca,Tagliabue, Aaron,Mihali, Voichita,Pilati, Tullio,Pecnikaj, Ilir,Penso, Michele
-
p. 3686 - 3689
(2013/08/23)
-
- Substituted benzene compounds as antiproliferative and cholesterol lowering action
-
The invention provides compounds, compositions and methods relating to novel electrophilic aromatic derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease st
- -
-
-
- Arylsulfonanilide phosphates
-
The invention provides compounds, compositions and methods relating to novel arylsulfonanilide derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, psoriasis, vascular restenosis, infrections, atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents.
- -
-
-
- Novel halogenated sulfonamides inhibit the growth of multidrug resistant MCF-7/ADR cancer cells
-
In this report, we describe the synthesis of halogenated benzenesulfonamide compounds and their ability to inhibit the growth of HeLa, MCF-7 and MCF-7/ADR tumor cells in vitro. The multidrug resistance (MDR) phenotype of certain cells does not affect their sensitivity to these compounds. These agents belong to a family of compounds previously shown to bind irreversibly to cysteine-239 of β-tubulin. Consistent with this mechanism of action, the cytotoxicities of these compounds appear to correlate with their ability to undergo nucleophilic aromatic substitution.
- Medina, Julio C.,Roche, Daniel,Shan, Bei,Learned, R. Marc,Frankmoelle, Walter P.,Clark, David L.,Rosen, Terry,Jaen, Juan C.
-
p. 1843 - 1846
(2007/10/03)
-