- HETEROCYCLIC INTEGRIN AGONISTS
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The present invention provides polycyclic oxothioxoimidazolidines, dioxoimidazolines, oxothioxooxazolidines, dioxooxazolidines, and related compounds, which are useful as integrin agonists. Methods for the treatment of integrin-mediated diseases such as cancer are also described.
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Paragraph 0234; 0236; 0265; 0266; 0275; 0277
(2018/07/29)
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- Selectivity in the photo-Fenton and photocatalytic hydroxylation of biphenyl-4-carboxylic acid and derivatives (viz. 4-phenylsalicylic acid and 5-phenylsalicylic acid)
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The selectivity of hydroxylation of the distal rings of 4-phenylbenzoic acid, 4-phenylsalicylic acid, and 5-phenylsalicylic acid were determined using partial TiO2-mediated photocatalytic degradation and photo-Fenton conditions. This separation of the binding site from the phenyl group being hydroxylated allows a less-biased evaluation. The hydroxylation regiochemistry behaves as qualitatively expected for an electrophilic reaction, given the assumption that 4-carboxyphenyl is a slightly electron-withdrawing substituent. Selectivity for hydroxylation of the distal phenyl in 4- and 5-phenylsalicylic acid is reversed, due to the reversal of the electronic demand, while adsorption to the TiO2 surface is assumed to be analogous for the two structures. Copyright
- Hathway, Timothy,Chernyshov, Deborah Lipman,Jenks, William S.
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supporting information
p. 1151 - 1156
(2013/01/09)
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- 1H-INDOLE-2-CARBOXYLIC ACID DERIVATIVES USEFUL AS PPAR MODULATORS
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The present invention relates to certain indole derivatives that are modulators of PPAR, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medicine.
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Page/Page column 65-66
(2008/06/13)
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