Synthesis of Fmoc-protected 4-carboxydifluoromethyl-L-phenylalanine: A phosphotyrosyl mimetic of potential use for signal transduction studies
4-(Carboxymethyl)phenylalanine (2) and its α,α-difluoro homologue 4- (carboxydifluoromethyl)-phenylalanine (3) have been described as phosphotyrosyl mimetics. Herein we report the synthesis of N-Fmoc 4-(O-tert- butyl carboxymethyl)phenylalanine (4) and N-
Yao, Zhu-Jun,Gao, Yang,Voigt, Johannes H.,Ford Jr., Harry,Burke Jr., Terrence R.
p. 2865 - 2874
(2007/10/03)
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