(Alkylsulfonyl)methanesulfonates as anticancer agents
Compounds of the formula: STR1 wherein R is methyl or other lower alkyl group; X and X' individually are hydrogen or lower alkyl; and R' is a 2-haloethyl group or other halogenated lower alkyl group are useful in the treatment of neoplastic diseases.
-
(2008/06/13)
2-Chloroethyl (methylsulfonyl)methanesulfonate and related (methylsulfonyl)methanesulfonates. Antineoplastic activity in vivo
2-Haloethyl and ethyl (methylsulfonyl)methanesulfonates were prepared via sulfene intermediates. 2-Chloroethyl (methylsulfonyl)methanesulfonate is highly active against P388 leukemia in vivo; the majority of leukemic mice treated with this compound at 50 mg/kg per day, qd 1-5, survived more than 30 days and about 37% survived for more than 60 days. 2-Fluoroethyl (methylsulfonyl)methanesulfonate is also highly effective against P388 cells in vivo, but it is more toxic. Other (methylsulfonyl)methanesulfonate esters are more active than the analogous methanesulfonates and chloromethanesulfonates.
Shealy,Krauth,Laster Jr.
p. 664 - 670
(2007/10/02)
More Articles about upstream products of 22317-89-1
