- 2'-O-MOE-3'-H-phosphorothioate nucleoside monomer and synthetic method thereof
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The invention discloses 2'-O-MOE-3'-H-phosphorodithioate ribonucleotide and 2'-O-MOE-3'-H-phosphorothioate ribonucleotide and precursor compounds thereof, preparation methods and applications of the 2'-O-MOE-3'-H-phosphorodithioate ribonucleotide and the
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Paragraph 0077; 0078
(2017/01/23)
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- 2′-Substituted RNA preparation
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A process for the preparation of a compound of formula (1): is provided, which comprises the reaction a compound of formula (2): with a compound of formula Al(OR)3 under substantially anhydrous conditions. X, and X1 are each independently H or a protecting group, B is a base; R is an alkyl, alkoxyalkyl, alkenyl or alkynyl group, each of which may be optionally substituted, and L is a leaving group.
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- 2'-SUBSTITUTED RNA PREPARATION
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A process for the preparation of a compound of formula (1): is provided, which comprises the reaction a compound of formula (2): with a compound of formula Al(OR)3 under substantially anhydrous conditions. X, and X1 are each independently H or a protecting group, B is a base; R is an alkyl, alkoxyalkyl, alkenyl or alkynyl group, each of which may be optionally substituted, and L is a leaving group.
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- Conversion of uridine into 2'-O-(2-methoxyethyl)uridine and 2'-O-(2- methoxyethyl)cytidine
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Reaction between aluminium 2-methoxyethoxide and 2,2'-anhydro-1-β-D- arabinofuranosyluracil 6 gives 2'-O-(2-methoxyethyl)uridine 9 in high yield. Compound 9 is converted into 2'-O-(2-methoxyethyl)cytidine 11 in good yield.
- Legorburu, Urtzi,Reese, Colin B.,Song, Quanlai
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p. 5635 - 5640
(2007/10/03)
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