Probing molecular shape. 1. Conformational studies of 5- hydroxyhexahydropyrimidine and related compounds
(Chemical Equation Presented) Understanding the factors that determine molecular shape enables scientists to begin to understand and tailor molecular properties and reactivity. Many biomolecules and bioactive compounds contain aliphatic heterocyclic rings whose conformations play a major role in their biological activity. The interplay of a number of factors, both steric and electronic, is examined for 5-hydroxyhexahydropyrimidine (1) and related compounds with use of spectroscopy and molecular modeling.
Locke, Julie M.,Crumbie, Robyn L.,Griffith, Renate,Bailey, Trevor D.,Boyd, Susan,Roberts, John D.
4-Substituted dioxolanes by chemoselective reactions on glycerol formal
4-Hydroxymethyl-1,3-dioxolane contained in glycerol formal undergoes chemoselective transformations, which constitute a direct entry to 4-substituted-1,3-dioxolanes.
Disclosed is a method for producing a 2-nitroimidazole derivative having an acyclic sugar chain in a side chain which is suitable for production of a derivative having a radioisotope. Specifically disclosed is a method for producing 1-(1- benzoyloxymethyl
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(2009/12/23)
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