Described herein are compounds, pharmaceutical compositions and methods for inhibiting the expression of a vitamin D receptor target gene, inhibiting interactions between the vitamin D receptor and at least one vitamin D receptor coactivator, for treating
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(2013/03/28)
Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators
The vitamin D receptor (VDR) is a nuclear hormone receptor that regulates cell proliferation, cell differentiation, and calcium homeostasis. The receptor is activated by vitamin D analogues that induce the disruption of VDR-corepressor binding and promote
Nandhikonda, Premchendar,Lynt, Wen Z.,McCallum, Megan M.,Ara, Tahniyath,Baranowski, Athena M.,Yuan, Nina Y.,Pearson, Dana,Bikle, Daniel D.,Guy, R. Kiplin,Arnold, Leggy A.
supporting information; experimental part
p. 4640 - 4651
(2012/07/03)
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