- Biphenyl dioxygenase-catalysed cis-dihydroxylation of tricyclic azaarenes: Chemoenzymatic synthesis of arene oxide metabolites and furoquinoline alkaloids
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Biotransformation of acridine, dictamnine and 4-chlorofuro[2,3-b]quinolone, using whole cells of Sphingomonas yanoikuyae B8/36, yielded five enantiopure cyclic cis-dihydrodiols, from biphenyl dioxygenase-catalysed dihydroxylation of the carbocyclic rings.
- Boyd, Derek R.,Sharma, Narain D.,Carroll, Jonathan G.,Loke, Pui L.,O'Dowd, Colin R.,Allen, Christopher C. R.
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p. 10944 - 10955
(2013/09/02)
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- cis-dihydrodiol, arene oxide and phenol metabolites of dictamnine: Key intermediates in the biodegradation and biosynthesis of furoquinoline alkaloids
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Biotransformation of the parent furoquinoline alkaloid dictamnine and its 4-chlorofuroquinoline precursor, using the B8/ 36 bacterial mutant strain of Sphingomonas yanoikuyae, yielded, via biphenyl dioxygenase-catalysed dihydroxylation, the first isolable alkaloid cis-dihydrodiol metabolites; these metabolites were used in the chemoenzymatic synthesis of postulated arene oxide and phenol intermediates, and a range of derived furoquinoline alkaloids. The Royal Society of Chemistry 2005.
- Boyd, Derek R.,Sharma, Narain D.,O'Dowd, Colin R.,Carroll, Jonathan G.,Loke, Pui L.,Allen, Christopher C. R.
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p. 3989 - 3991
(2007/10/03)
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