- Metathesis-active ligands enable a catalytic functional group metathesis between aroyl chlorides and aryl iodides
-
Current methods for functional group interconversion have, for the most part, relied on relatively strong driving forces which often require highly reactive reagents to generate irreversibly a desired product in high yield and selectivity. These approaches generally prevent the use of the same catalytic strategy to perform the reverse reaction. Here we describe a catalytic functional group metathesis approach to interconvert, under CO-free conditions, two synthetically important classes of electrophiles that are often employed in the preparation of pharmaceuticals and agrochemicals—aroyl chlorides (ArCOCl) and aryl iodides (ArI). Our reaction design relies on the implementation of a key reversible ligand C–P bond cleavage event, which enables a non-innocent, metathesis-active phosphine ligand to mediate a rapid aryl group transfer between the two different electrophiles. Beyond enabling a practical and safer approach to the interconversion of ArCOCl and ArI, this type of ligand non-innocence provides a blueprint for the development of a broad range of functional group metathesis reactions employing synthetically relevant aryl electrophiles.
- Lee, Yong Ho,Morandi, Bill
-
p. 1016 - 1022
(2018/09/06)
-
- A simple and effective copper catalyst for the conversion of arylboronic acids to aryl iodides at room temperature
-
Simple Cu(NO3)2·3H2O was demonstrated to be of ability to catalyze the conversion of arylboronic acids to aryl iodides at room temperature. Compared with the previous copper-catalyzed method, the present procedure avoids the use of the ligand, the oxidant as well as the heating condition.
- Ren, Yun-Lai,Tian, Xin-Zhe,Dong, Chuanhua,Zhao, Shuang,Wang, Jianji,Yan, Mengjie,Qi, Xiaoguang,Liu, Guihua
-
-
- Method for producing tetrakis ( fluoroaryl) borate-magnesium compound
-
Fluoroaryl magnesium halide is reacted with a boron compound so that a molar ratio of the fluoroaryl magnesium halide to the boron compound is not less than 3.0 and not more than 3.7, so as to produce a tetrakis (fluoroaryl) borate·magnesium compound. With this method, there occurs no hydrogen fluoride which corrodes a producing apparatus and requires troublesome waste water treatment.
- -
-
-
- Synthesis and mesomorphic properties of some liquid crystals with 2,3,5,6-tetrafluorophenylene unit
-
Nine fluorosubstituted liquid crystals have been synthesized and their mesomorphic properties have been studied by texture observation in a polarizing microscope and confirmed by DSC. They show enantiotropic smectic A and nematic phases. The effect of ter
- Tang,Yang, Yong Gang,Wen
-
-