- CRYSTAL FORMS OF 4-[4-(4-FLUOROPHENOXY)BENZENESULFONYLAMINO]-TETRAHYDROPYRAN-4-CARBOXYLIC ACID HYDROXYAMIDE
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The present invention relates to a new crystal form of the compound 4-[4-(4-fluorophenoxy)benzenesulfonylamino]-tetrahydropyran-4-carboxylic acid hydroxyamide, combinations of forms of that compound, compositions containing one or more forms of the compound, processes for preparing forms of the compound and compositions containing one or more of them, and the use of one or more forms of the compound and compositions containing one or more of them in treating medical disorders. The invention also provides a new form of the compound 4-[4-(4-fluorophenoxy)benzenesulfonyl amino]-tetrahydropyran-4- carboxylic acid hydroxyamide which is referred to as Form B.
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- Reaction of chloro(chlorodimethyl)dimethylsilane with O-silylurethanes and nicotinic hydrazide in the presence of hexamethyldisilazane
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The reaction of chloro(chlorodimethyl)dimethylsilane and hexamethyldisilazane with O-silylurethanes and nicotinic hydrazide gives rise to products whose structure is determined by the composition, structure, and basicity of intermediate compounds. The rea
- Kirilin,Belova,Zhvakina,Chernyshev
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p. 1539 - 1542
(2007/10/03)
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- Synthesis of N-(dialkoxyphosphoroyl)-O-(p-nitrophenylsulfonyl)-hydroxylamines - Potential reagents for electrophilic amination
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Synthesis of the title compounds by phosphorylation of O-trimethylsilylhydroxylamine followed by methanolysis and O-nosylation of the 'in situ' formed N-phosphoroylhydroxylamines has been described.
- Koziara,Nowalinska,Zwierzak
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p. 2127 - 2133
(2007/10/02)
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- Process for the preparation of isocyanates and their use for the preparation of polyisocyanates containing ester
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This invention relates to a novel process for the preparation of isocyanates containing silylated alcoholic or phenolic hydroxyl groups as substituents and to the use of the compounds obtained by this process as reactants for isocyanatocarboxylic acid halides in the preparation of polyisocyanates containing ester groups.
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- EXPEDIENT SYNTHESIS OF MONO-TRIMETHYLSILYL HYDROXYLAMINE AND BIS-TRIMETHYLSILYL HYDROXYLAMINE
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Mono and Bis-trimethylsilylhydroxylamine are conveniently prepared by similar procedures on an arbitrarily large scale, without risk or undue effort on the part of the experimenter.
- Bottaro, Jeffrey C.,Bedford, Clifford D.,Dodge, Allen
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p. 1333 - 1336
(2007/10/02)
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- Preparation and Characterisation of N-(Diphenylphosphinoyl)hydroxylamine, and Conversion into O-Sulphonyl Derivatives that undergo Lossen-like Rearrangement
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Having previously shown that diphenylphosphinic chloride (1a) forms O-(diphenylphosphinoyl)hydroxylamine (3a) with hydroxylamine, we have now established that N-(diphenylphosphinoyl)hydroxylamine (2a) can be obtained in good yield by reaction of (1a) with O-trimethylsilylhydroxylamine followed by methanolytic removal of the silyl blocking group.The di-p-tolyl (2b) and bis-p-methoxyphenyl (2c) analogues can be prepared in a similar way.N-(Diphenylphosphinoyl)hydroxylamine is acetylated at the O atom with acetic anhydride, and is sulphonylated at O with methanesulphonyl chloride and toluene-p-sulphonyl chloride.The N-(diphenylphosphinoyl)-O-sulphonylhydroxylamines (8) and (12a) undergo rapid and quantitative Lossen-like rearrangement with methanol-sodium methoxide to give methyl N,P-diphenylphosphonamidate (11).Comparable rearrangement are observed with t-butylamine, aniline-triethylamine, and phenol-triethylamine.
- Harger, Martin J. P.
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p. 2699 - 2704
(2007/10/02)
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