Addition of 2-tert-butyldimethylsilyloxythiophene to activated quinones: An approach to thia analogues of kalafungin
The uncatalyzed reaction of 2-tert-butyldimethylsilyloxythiophene 2 with 1,4-quinones bearing either an electron withdrawing acetyl or a carbomethoxy group at C-2, was investigated. No reaction was observed using 1,4-quinones 8 and 9 bearing an ester grou
Brimble, Margaret A.,Laita, Olivia,Robinson, James E.
THIENYL BENZOTHIENYL AND DIBENZOTHIENYL COMPOUNDS AS INHIBITORS OF ALDOSE REDUCTASE
The invention concerns heterocyclic nitromethane derivatives of the formula 1 as defined hereinafter (and their non-toxic salts) wherein the heterocyclic moiety Q is thienyl, benzothienyl or dibenzothienyl and may bear a wide variety of optional substituents, together with pharmaceutical compositions containing them. The nitromethane derivatives are inhibitors of the enzyme aldose reductase and are of value in the treatment of certain complications of diabetes and galactosemia
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(2008/06/13)
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