cas 23396-50-1, 3-HYDROXY-3-PHENYL-PIPERIDINE | Articles data ｜lookchem

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23396-50-1

Articles about 23396-50-1Total 4 be found

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CHIRAL AUXILIARIES
Chiral auxiliaries useful for efficiently producing a phosphorus atom-modified nucleic acid derivative with high stereoregularity, and compounds represented by the following the general formula (I) or the general formula (XI) for introducing the chiral auxiliaries.
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(2013/07/19)

Novel piperidyl derivatives of quinazoline and isoquinoline
The invention pertains to new piperidyl-substituted quinazoline and isoquinoline derivatives that serve as effective phosphodiesterase (PDE) inhibitors. The invention also relates to compounds that are selective inhibitors of PDE10. The invention further relates to intermediates for preparation of such compounds; pharmaceutical compositions comprising such compounds; and the use of such compounds in methods for treating certain central nervous system (CNS) or other disorders.
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Page/Page column 23

(2010/02/15)

Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists
A series of 3-aryl piperidine analogs with 2-piperidinoalkylamino or 2-piperidinoalkyloxy fused bicyclic rings were prepared and found to be potent and efficacious human dopamine D4 agonists. The synthesis and structure-activity relationship (SAR) studies that led to the identification of these compounds are discussed.
Wang, Xueqing,Bhatia, Pramila A.,Daanen, Jerome F.,Latsaw, Steve P.,Rohde, Jeffrey,Kolasa, Teodozyi,Hakeem, Ahmed A.,Matulenko, Mark A.,Nakane, Masaki,Uchic, Marie E.,Miller, Loan N.,Chang, Renjie,Moreland, Robert B.,Brioni, Jorge D.,Stewart, Andrew O.
p. 4667 - 4678
(2007/10/03)

An efficient synthesis of N-aroyl-3-phenyltetrahydropyridines
N-Aroyl-3-phenyltetrahydropyridines were conveniently synthesized by dehydration of N-aroyl-3-hydroxy-3-phenylpiperidines with toluenesulfonic acid on silica gel as a dehydration reagent.
Sui, Zhihua,Dodd, John,Ohemeng, Kwasi A.
p. 175 - 185
(2007/10/03)

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Chemical Properties

Melting Point: 91-92 °C
Boiling Point: 300.144 °C at 760 mmHg
Flash Point:120.465 °C
Density: 1.093 g/cm³
Vapor Pressure: 0.001mmHg at 25°C
Refractive Index: 1.559
PKA: 14.09±0.20(Predicted)
PSA: 32.26000
LogP: 1.58640

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