Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2
The identification, synthesis and evaluation of a series of rhodanine and thiazolidin-2,4-dione derivatives as selective inhibitors of human arylamine N-acetyltransferase 1 and mouse arylamine N-acetyltransferase 2 is described. The most potent inhibitors
Russell, Angela J.,Westwood, Isaac M.,Crawford, Matthew H.J.,Robinson, James,Kawamura, Akane,Redfield, Christina,Laurieri, Nicola,Lowe, Edward D.,Davies, Stephen G.,Sim, Edith
experimental part
p. 905 - 918
(2009/09/25)
SAR and mode of action of novel non-nucleoside inhibitors of hepatitis C NS5b RNA polymerase
Novel non-nucleoside inhibitors of the HCV RNA polymerase (NS5b) with sub-micromolar biochemical potency have been identified which are selective for the inhibition of HCV NS5b over other polymerases. The structures of the complexes formed between several
Powers, Jay P.,Piper, Derek E.,Li, Yang,Mayorga, Veronica,Anzola, John,Chen, James M.,Jaen, Juan C.,Lee, Gary,Liu, Jinqian,Peterson, M. Greg,Tonn, George R.,Ye, Qiuping,Walker, Nigel P. C.,Wang, Zhulun
p. 1034 - 1046
(2007/10/03)
POTASSIUM FLUORIDE ON ALUMINA: CONDENSATION OF 3-METHYL-2-THIONO-4-THIAZOLIDINONE WITH ALDEHYDES. SYNTHESIS OF α-THIOACRYLIC ACIDS AND PHOSPHONOTHIONOTHIAZOLIDINONES
3-Methyl-2-thiono-4-thiazolidinone and aromatic aldehydes adsorbed on potassium fluoride on alumina gave under microwave irradiation 5-arylidene-3-methyl-2-thiono-4-thiazolidinones in 70percent to 90percent yield.These compounds can be cleaved with sodium
Villemin, Didier,Alloum, Abdelkrim Ben
p. 33 - 42
(2007/10/02)
Studies on 4-Thiazolidinones. VI. Reactions of 5-Arylmethylene-2-alkylthio-2-thiazolin-4-ones with Ammonium Carbonate and Amines
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Omar, M.T.,Sherif, F.A.
p. 835 - 842
(2007/10/02)
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