- PHOSPHONYLATION BY TETRAPHOSPHORUS HEXOXIDE
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The general usefulness of P4O6 as starting material for the preparation of inorganic and organic phosphorus compounds is demonstrated by reactions of P4O6 with nucleophilic and electrophilic compounds.
- Schuelke, Ulrich
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p. 623 - 626
(2007/10/02)
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- Phosphonohydroxyacetonitrile, a process for its preparation and its use as an intermediate product for the preparation of medicaments
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The invention relates to phosphonodroxyacetonitrile and a process for its production which comprises reacting phosphono formaldehyde, in salt form, with hydrocyanic acid (then, if desired, converting the free phosphonohydroxyacetonitrile to salt thereof. The phosphonohydroxyacetonitrile is useful, for example, as an intermediate for the production of phosphonohydroxyacetic acid, an antiviral agent.
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- Phosphono-hydroxy-acetic acid and its salts, their production and their medicinal use
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The invention relates to phosphono-hydroxyacetic acid and salts thereof of Formula I as defined hereinabove, useful as antiviral agents, e.g. antiherpes agents. Also included in the invention are pharmaceutical compositions and medicaments containing said compounds of Formula I as the active ingredients as well as methods for the use of said compounds, compositions and medicaments.
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