- A terphenyl phosphine as a highly efficient ligand for palladium-catalysed amination of aryl halides with 1° anilines
-
A terphenyl phosphine ligand (2,6-bis(2,4,6-triisopropylphenyl)phenyl-dicyclohexylphosphine, TXPhos) and its supported palladium complex [(TXPhos)(allyl)PdCl] have been developed and the catalyst system is highly efficient in amination of aryl halides with 1° anilines, especially effective for densely functionalized substrates including both partners possessing ortho-ester, acetyl, nitrile and nitro groups. With the TXPhos-supported catalyst system, many partner combinations have been unprecedentedly realized and the base scope has been even extended to KOAc, which is even the best choice in the amination of 2-nitrochlorobenzene.
- Shi, Ji-cheng,Zhang, Lixue,Zhou, Fabin
-
p. 238 - 243
(2021/09/07)
-
- Packed-bed reactors for continuous-flow C-N cross-coupling
-
Take a C-N bond and make it better: The optimized conditions for continuous-flow palladium-catalyzed C-N bond-forming reactions have been determined. They require the use of aqueous KOH, toluene as the solvent, tetrabutylammonium bromide as a phase-transfer catalyst, and a packed-bed microreactor (see scheme; TBAB=tetrabutylammonium bromide). In some cases, peforming these reactions under harsh conditions led to greatly enhanced reaction rates. Copyright
- Naber, John R.,Buchwald, Stephen L.
-
supporting information; experimental part
p. 9469 - 9474
(2011/02/25)
-
- Substituted aminobenzoates, their preparation and use
-
Novel lower-alkyl 2-(hydroxyphenylamino)benzoates, useful as inhibitors of lipoxygenase, are of the formula STR1 wherein R is hydrogen, lower-alkyl or lower-alkoxy; R' is hydrogen or lower-alkyl; R" is hydrogen, lower-alkyl or halo; and Alk is lower-alkyl. The compounds are prepared by de-etherification of the corresponding alkyl or benzyl ethers.
- -
-
-