Approach to the synthesis of 8-nitroquinoline-2-carboxylic acid in high yield
A synthesis of 8-nitroquinoline-2-carboxylic acid was optimized, using the following basic scheme of transformations: 1) nitration of 2-methylquinoline with subsequent separation of a mixture of isomeric 8-nitroand 5-nitro-2-methylquinolines; 2) oxidation of the methyl group in 2-methyl-8-nitroquinoline (including consecutive steps of bromination and hydrolysis in aqueous sulfuric acid). A new method for the separation of isomeric 8-nitroand 5-nitro-2methylquinolines was suggested. The optimal conditions for the final step of hydrolysis were selected, which gave almost quantitative yield of 8-nitroquinoline-2-carboxylic acid.
Gadomsky, S. Ya.,Yakuschenko
p. 816 - 818
(2016/12/27)
Substitution effect on the one- and two-photon sensitivity of DMAQ "caging" groups
The systematic SAR study of a "caging" group showed a strong influence of the position of the donor dimethylamino group on the efficiency of photolysis of the DMAQ (2-hydroxymethylene-(N,N-dimethylamino)quinoline) caged acetate under one-photon near-UV or two-photon near-IR excitation. Photorelease of l-glutamate by the most efficient 8-DMAQ derivative strongly and efficiently activated glutamate receptors, generating large, fast rising responses similar to those elicited by glutamate photoreleased from the widely used MNI-caged glutamate.
Petit, Morgane,Tran, Christine,Roger, Thomas,Gallavardin, Thibault,Dhimane, Hamid,Palma-Cerda, Francisco,Blanchard-Desce, Mireille,Acher, Francine C.,Ogden, David,Dalko, Peter I.
supporting information
p. 6366 - 6369
(2013/02/23)
5-SUBSTITUTED QUINOLINE AND ISOQUINOLINE DERIVATIVES, A METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS ANTIPHLOGISTICS
The invention relates to compounds of general formulas (IIa) or (IIb) and to their use as medicaments.
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Page/Page column 28
(2008/06/13)
Syntheses of Novel Quinolone-Chemotherapeutics, I: Pyridoquinolines and Pyridophenanthrolines as Derivatives of "lin-benzo-Nalidixic Acid"
Expansion of nalidixic acid (NA) has been accomplished by linear insertion of a benzo-ring between the two pyrido moieties.The resulting compounds exhibit antibacterial activity comparable to NA and are highly fluorescent.The regioselective hydrogenation of 1,7-phenanthrolines was studied. - Keywords: lin-Benzo-analogs; Quinolones; Pyridoquinoline; Pyridophenanthroline; Pyridophenanthroline; Regioselective hydrogenation of phenanthrolines; Fluorescence
Jordis, U.,Sauter, F.,Rudolf, M.,Cai, Gan
p. 761 - 780
(2007/10/02)
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