- Sodium Hypochlorite Pentahydrate as a Reagent for the Cleavage of trans-Cyclic Glycols
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Sodium hypochlorite pentahydrate (NaOCl·5H2O) can be used toward the efficient glycol cleavage of trans-cyclic glycols, which are generally resistant to this transformation. Interestingly, the reaction of cis-cyclic glycols with NaOCl·5H2O is slower than that observed for the corresponding trans-isomer. This trans selectivity is in sharp contrast to traditional oxidants used for glycol cleavage. Acyclic glycols can also react efficiently with NaOCl·5H2O to form their corresponding carbonyl compounds in high yield.
- Kirihara, Masayuki,Osugi, Rie,Saito, Katsuya,Adachi, Kouta,Yamazaki, Kento,Matsushima, Ryoji,Kimura, Yoshikazu
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p. 8330 - 8336
(2019/06/24)
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- Weak Coordination Promoted Regioselective Oxidative Coupling Reaction for 2,2′-Difunctional Biaryl Synthesis in Hexafluoro-2-propanol
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An unprecedented weak coordination promoted dehydrogenative cross-coupling reaction has been developed by palladium catalysis, which provides a convenient access to a wide range of 2,2′-difunctional biaryls from easily accessible substrates. Both HFIP solvent and oxidants serve as the critical factors in this new reaction. A plausible mechanism involving Pd(II)/Pd(IV) is proposed. The reaction demonstrates excellent reactivity, broad functional-group tolerance and high yields.
- Zhang, Chao,Rao, Yu
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supporting information
p. 4456 - 4459
(2015/09/28)
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- Nickel phosphate catalysts
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Methods for coupling aryl halides or aryl sulfonates to produce biaryls or polyaryls using novel nickel phosphite catalysts are provided.
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- Approaches towards the synthesis of a sulfur analog of ergosterol peroxide
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In an analogous fashion to the preparation of ergosterol peroxide from singlet oxygen, the preparation of its sulfur analog was attempted via the Diels-Alder addition of diatomic sulfur to ergosterol.Two of the recently reported methods for generating and
- Tsantrizos, Youla S.,Folkins, Patricia L.,Britten, James F.,Harpp, David N.,Ogilvie, Kelvin K.
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p. 158 - 164
(2007/10/02)
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- Syntheses and Chemistry of Some Dibenzazepines
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5-Methyl-, 5,7-dimethyl-, and 5,7-diphenyl-substituted and unsubstituted 5H-dibenzazepines were prepared by two general routes from -2,2'-dicarboxaldehyde.The unsubstituted dibenzazepine was converted into 1a,9b-dihydrophenanthro9,10-
- Weitzberg, Moshe,Abu-Shakra, Elias,Azeb, Abdullatif,Aizenshtat, Zeev,Blum, Jochanan
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p. 529 - 536
(2007/10/02)
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- Ni(0)-TRIALKYLPHOSPHINE COMPLEXES. EFFICIENT HOMO-COUPLING CATALYST FOR ARYL, ALKENYL, AND HETEROAROMATIC HALIDES.
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Bis(trialkylphosphine)nickel(0) generated in situ from bis(trialkylphosphine)nickel(II) chloride was found to be an effective catalyst for a homo-coupling of aryl, alkenyl, or heteroaromatic halides with zinc powder. The catalytic reaction proceeded very well in NMP or HMPA solvent under mild conditions to afford dehalogenative-coupling products in good yields.
- Takagi,Hayama,Sasaki
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p. 1887 - 1890
(2007/10/02)
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- PALLADIUM-CATALYSED CYCLISATION OF 2-SUBSTITUTED HALOGENOARENES BY DEHYDROHALOGENATION
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Cyclodehydrohalogenation mediated by various palladium catalysts and solvents with different bases (the most generally satisfactory system being palladium(II) acetate in NN-dimethylacetamide (DMA) with sodium carbonate as base) has been examined as a route to some heterocyclic systems.Whereas dehydrogenative cyclisation processes require stoichiometric amounts of palladium(II) reagent, the present procedure involves only catalytic amounts (0.1 molar proportion, or less), of palladium compound.The preparation of dibenzofuran, carbazole, fluorenone, 6H-dibenzothiazine-5,5-dioxide, 6H-dibenzopyran and benzofuranopyridine derivatives is described.The cyclisation of 3-benzamido-2-chloropyridine to 6-hydroxybenzonaphthiridine illustrates the regiospecificity of the process.
- Ames, D.E.,Opalko, A.
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p. 1919 - 1926
(2007/10/02)
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