- Rational Design of Efficient Organic Phototherapeutic Agents via Perturbation Theory for Enhancing Anticancer Therapeutics
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The development of efficient phototherapeutic agents (PTA) through rational and specific principles exhibits great potential to the biomedical field. In this study, a facile and rational strategy was used to design PTA through perturbation theory. Accordi
- Xu, Yunjian,Zhao, Menglong,Wu, Licai,Li, Feiyang,Li, Mingdang,Xie, Mingjuan,Liu, Shujuan,Huang, Wei,Zhao, Qiang
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Read Online
- Synthesis and mesomorphic properties of new methylene-linked linear symmetrical liquid crystal dimers
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A series of methylene-linked symmetrical liquid crystal dimers were synthesized. Their structures were confirmed by physicochemical techniques. Differential scanning calorimetry and polarizing optical microscopy verified the liquid crystal behaviors and t
- Al-Hamdani, Uhood J.,Al-Ibrahim, Aiman G.,Abbo, Hanna S.,Titinchi, Salam J.J.
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Read Online
- "colored" inorganic dopants for inducing liquid crystal chiral nematic and blue phases: Monitoring of dopant-host interaction by Raman spectroscopy
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A new ruthenium complex that effectively induces chiral nematic and blue phases upon doping with a nematic liquid crystal was developed. The red-colored dopant exhibits strong Raman scattering in solution and nematics even at low concentrations. Further m
- Yoshida, Jun,Tamura, Shuhei,Watanabe, Go,Kasahara, Yasutoshi,Yuge, Hidetaka
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- Novel Fluorescent Fluorene-Containing Conjugated Polymers: Synthesis, Photophysical Properties, and Application for the Detection of Common Bisphenols
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Eight new fluorescent conjugated polymers were synthesized by the Suzuki polycondensation reaction of 9,9-dioctylfluorene-2,7-diboronic acid bis(1,3-propanediol) ester and a conjugated dihalogenated monomer. The photophysical properties of these polymers were investigated as well-dissolved solutions in chloroform and as nanoparticle suspensions in water. Several of the polymers had large Stokes shifts (greater than 100 nm) and others demonstrated unique changes in the fluorescence properties in aggregated verse nonaggregated forms. Preliminary applications of these polymers in the detection of common bisphenols are also reported.
- Jones, Daniel R.,Vallee, Ryan,Levine, Mindy
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Read Online
- Synthesis, mesomorphism, photophysics and device performance of liquid-crystalline pincer complexes of gold(iii)
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Emissive gold(iii) complexes of pincer 2,6-diphenylpyridines also bearing a phenylacetylide ligand have been modified at both the pincer and phenylacetylide to confer liquid crystalline properties, with most complexes showing a columnar hexagonal phase in
- Parker, Rachel R.,Liu, Denghui,Yu, Xiankang,Whitwood, Adrian C.,Zhu, Weiguo,Williams,Wang, Yafei,Lynam, Jason M.,Bruce, Duncan W.
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supporting information
p. 1287 - 1302
(2021/02/12)
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- Lipophilic tail modifications of 2-(hydroxymethyl)pyrrolidine scaffold reveal dual sphingosine kinase 1 and 2 inhibitors
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The sphingosine 1-phosphate (S1P) signaling pathway is an attractive target for pharmacological manipulation due to its involvement in cancer progression and immune cell chemotaxis. The synthesis of S1P is catalyzed by the action of sphingosine kinase 1 or 2 (SphK1 or SphK2) on sphingosine and ATP. While potent and selective inhibitors of SphK1 or SphK2 have been reported, development of potent dual SphK1/SphK2 inhibitors are still needed. Towards this end, we report the structure–activity relationship profiling of 2-(hydroxymethyl)pyrrolidine-based inhibitors with 22d being the most potent dual SphK1/SphK2 inhibitor (SphK1 Ki = 0.679 μM, SphK2 Ki = 0.951 μM) reported in this series. 22d inhibited the growth of engineered Saccharomyces cerevisiae and decreased S1P levels in histiocytic lymphoma myeloid cell line (U937 cells), demonstrating inhibition of SphK1 and 2 in vitro. Molecular modeling studies of 22d docked inside the Sph binding pocket of both SphK1 and SphK2 indicate essential hydrogen bond between the 2-(hydroxymethyl)pyrrolidine head to interact with aspartic acid and serine residues near the ATP binding pocket, which provide the basis for dual inhibition. In addition, the dodecyl tail adopts a “J-shape” conformation found in crystal structure of sphingosine bound to SphK1. Collectively, these studies provide insight into the intermolecular interactions in the SphK1 and 2 active sites to achieve maximal dual inhibitory activity.
- Li, Hao,Sibley, Christopher D.,Kharel, Yugesh,Huang, Tao,Brown, Anne M.,Wonilowicz, Laura G.,Bevan, David R.,Lynch, Kevin R.,Santos, Webster L.
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- 1,3-Oxazine-2-one derived dual-targeted molecules against replicating and non-replicating forms of Mycobacterium tuberculosis
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The high mortality rate and increasing prevalence of resistant Mtb are the major concerns for the Tuberculosis (TB) treatment in this century. To curtail the prevalence of resistant Mtb, we have prepared 1,3-oxazine-2-one based dual targeted molecules. Compound 67 and 68 were found to be equally active against replicating and non-replicatiing form of Mtb (MICMABA 3.48 and 2.97 μg/ml; MICLORA 2.94 and 2.15 μg/ml respectively). They had found to suppress the biosynthesis of alfa, methoxy and keto-mycolate completely, as well as inhibit enzymatic activity of MenG (IC50 = 9.11 and 6.25 μg/ml respectively for H37Ra; IC50 = 11.76 and 10.88 μg/ml respectively for M smegmatis).
- Velappan, Anand Babu,Kesamsetty, Dhanunjaya,Datta, Dhrubajyoti,Ma, Rui,Hari, Natarajan,Franzblau, Scott G.,Debnath, Joy
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supporting information
(2020/10/02)
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- 2-Aryl benzazole derived new class of anti-tubercular compounds: Endowed to eradicate mycobacterium tuberculosis in replicating and non-replicating forms
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The high mortality rate and the increasing prevalence of Mtb resistance are the major concerns for the Tuberculosis (TB) treatment in this century. To counteract the prevalence of Mtb resistance, we have synthesized 2-aryl benzazole based dual targeted molecules. Compound 9m and 9n were found to be equally active against replicating and non-replicating form of Mtb (MIC(MABA) 1.98 and 1.66 μg/ml; MIC(LORA) 2.06 and 1.59 μg/ml respectively). They arrested the cell division (replicating Mtb) by inhibiting the GTPase activity of FtsZ with IC50 values 45 and 64 μM respectively. They were also capable of kill Mtb in non-replicating form by inhibiting the biosynthesis of menaquinone which was substantiated by the MenG inhibition (IC50 = 11.62 and 7.49 μM respectively) followed by the Vit-K2 rescue study and ATP production assay.
- Datta, Dhrubajyoti,Debnath, Joy,Franzblau, Scott G.,Ghosh, Kalyan Sundar,Hari, Natarajan,Ma, Rui,Rana, Shiwani,Velappan, Anand Babu
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- Effect of New Analogs of Hexyloxy Phenyl Imidazoline on Quorum Sensing in Chromobacterium violaceum and in Silico Analysis of Ligand-Receptor Interactions
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The increasing common occurrence of antibiotic-resistant bacteria has become an urgent public health issue. There are currently some infections without any effective treatment, which require new therapeutic strategies. An attractive alternative is the design of compounds capable of disrupting bacterial communication known as quorum sensing (QS). In Gram-negative bacteria, such communication is regulated by acyl-homoserine lactones (AHLs). Triggering of QS after bacteria have reached a high cell density allows them to proliferate before expressing virulence factors. Our group previously reported that hexyloxy phenylimidazoline (9) demonstrated 71% inhibitory activity of QS at 100 μM (IC50 = 90.9 μM) in Chromobacterium violaceum, a Gram-negative bacterium. The aim of the present study was to take 9 as a lead compound to design and synthesize three 2-imidazolines (13-15) and three 2-oxazolines (16-18), to be evaluated as quorum-sensing inhibitors on C. violaceum CV026. We were looking for compounds with a higher affinity towards the Cvi receptor of this bacterium and the ability to inhibit QS. The binding mode of the test compounds on the Cvi receptor was explored with docking studies and molecular dynamics. It was found that 8-pentyloxyphenyl-2-imidazoline (13) reduced the production of violacein (IC50 = 56.38 μM) without affecting bacterial growth, suggesting inhibition of quorum sensing. Indeed, compound 13 is apparently one of the best QS inhibitors known to date. Molecular docking revealed the affinity of compound 13 for the orthosteric site of N-hexanoyl homoserine lactone (C6-AHL) on the CviR protein. Ten amino acid residues in the active binding site of C6-AHL in the Cvi receptor interacted with 13, and 7 of these are the same as those interacting with AHL. Contrarily, 8-octyloxyphenyl-2-imidazoline (14), 8-decyloxyphenyl-2-imidazoline (15), and 9-decyloxyphenyl-2-oxazoline (18) bound only to an allosteric site and thus did not compete with C6-AHL for the orthosteric site.
- Bello, Martiniano,Correa-Basurto, José,Curiel-Quesada, Everardo,Herrera-Arizmendi, José Luis,Reyes-Arellano, Alicia
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- Side chain modified porphyrin molecules and application thereof
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The invention discloses side chain modified porphyrin molecules and application thereof. According to the side chain modified porphyrin molecules, porphyrin molecules with electron enriching functionsare adopted as a core of capturing charges, an alkoxy chain segment is adopted as an inhibition part of a charge transfer process, and the molecules are ensured to be applied to flexible structures for solution processing. Molecule structures are reasonably designed from the view of film morphologies, preparation processes and performance regulation and control, and properties of organic field effect transistor storage devices are compared. The invention provides a material and device preparation method which is feasible in commercial popularization, low in cost and simple in process while properties of storage devices are regulated.
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Paragraph 0068; 0072-0073
(2019/12/25)
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- Highly frustrated liquid crystal phases in optically active dimers: Synthesis and rich phase transitional behavior
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Herein we report on the synthesis and characterization of four new series of optically active, nonsymmetric dimers in which cholesterol is covalently linked to a Schiff base core through an ω-oxyalkanoyl spacer. While the Schiff base core is substituted with n-butyloxy, n-hexyloxy, n-octyloxy, n-decyloxy and n-dodecyloxy tails, three even-parity spacers, namely, 4-oxybutanoyl, 6-oxyhexanoyl, 8-oxyoctanoyl, and an odd-parity spacer, namely, 5-oxypentanoyl, have been used to join the two cores. The experimental results show that the length and parity of the spacer and the length of the terminal tail play a vital role in deciding the phase sequences of the dimers. In general, the dimers possessing an even-parity spacer display enantiotropic LC phases such as chiral nematic (N?), twist grain boundary (TGB), smectic A (SmA), chiral smectic C (SmC?) and twist grain boundary phase with SmC? slabs (TGBC?). Some of these dimers display TGBC? over a wide temperature range. The dimers with an odd-parity (5-oxypentanoyl) spacer display, unlike their even-membered counterparts, blue phases (BPIII/II/I); besides, they stabilize N? and/or unknown smectic (SmX) phases. The circular dichroism (CD) measurements were carried out as a function of temperature on the planar texture formed by three even-membered dimers and an odd-membered dimer. The occurrence of a strong negative CD band in the N? phase of the even-membered dimers suggests a left-handed screw sense of the macroscopic helical structure, and the scenario is opposite in the case of an odd-membered dimer.
- Nayak, Rashmi Ashwathama,Bhat, Sachin A.,Shanker,Rao, D. S. Shankar,Yelamaggad
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supporting information
p. 2148 - 2162
(2019/02/05)
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- “Effect of the linking unit on the calamitic-shaped liquid crystal: a comparative study of two homologous series of benzoate and cinnamate linked compounds”
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Two homologous series based on three linking groups have been synthesized and well characterized by elemental analyses and spectroscopic techniques such as Fourier transform infrared [FT-IR] and proton magnetic resonance magnetic resonance [1H NMR] spectroscopy. The mesomorphic properties of these compounds were observed by using optical polarized microscopy (POM) and confirmed by differential scanning calorimetry (DSC) analysis. In this present investigation, we have synthesized two homologous series viz. (E)-4-(3-(4-(tetra decanoyloxy) phenyl) acryloyl) phenyl-4-n-alkoxy benzoate (Series-1) and 4-((E)-3-(4-(((E)-3-(4-n-alkoxy phenyl) acryloyl) oxy) phenyl)-3-oxo prop-1-en-1-yl) phenyl tetradecanoate (Series-2). Both of the series are differing with respect to the first linking group. All the homologous in following series displays LC properties on heating as well as cooling condition except first four homologous (C1 to C4) in series-1 and six homologous (C1 to C6) in series-2. To get more insights, the HOMO, LUMO studies are carried out which supports intramolecular charge transfer interactions in this class of mesogens.
- Kashyap, Dinesh,Patel, Sunil,Prajapat, Varsha,Sharma, Vinay,Vasava, Dilip
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- Mesomorphism behaviour and photoluminescent properties of new asymmetrical 1,2-di(4-alkoxybenzylidene) hydrazines
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{1-[4-(n-Alkoxy)]-2-(4’-decyloxy)benzylidene}hydrazines (n-alkoxy = O(CH2)nH, n = 1–9, 12, 16 or 18), an asymmetrical series of 1,2-disubstituted hydrazines, were prepared in a simple two-step procedure as a part of our continuing work in evaluating hydrophobic azine compounds as photoluminescent liquid crystalline materials. The compounds were characterized spectroscopically and their liquid crystalline behaviour and luminescent properties were evaluated using polarized light optical microscopy, differential scanning calorimetry and X-ray powder diffraction techniques. The studies revealed that all of these compounds are liquid crystalline materials exhibiting photoluminescent properties in the crystalline and liquid crystal states.
- Awad, Adil A.,Omarali, Al-Ameen Bariz,Al-Karawi, Ahmed Jasim M.,Al-Qaisi, Zyad Hussein J.,Majeed, Samer Ghanim
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- Effect of regioisomerism on the self-assembly, photophysical and gelation behavior of aroylhydrazone based polycatenars: Synthesis and characterization
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In this paper we report five series of aroylhydrazone based polycatenars differing from each other in number and position of alkoxy chains on one end of the core; keeping other end the same. A systematic variation in the structures was carried out to understand the effect of position and chain length on the mesophase behavior. In the case of single alkoxy chain at 4-position, there is a transition from Smectic C to Smectic A mesophase during cooling and Smectic A to Smectic C transition in heating cycle in all the homologues except n = 6 & n = 8. In the case of two alkoxy chains at 3-, 5-positions, the compounds are non-mesogenic in nature. On changing the position of alkoxy chains from 3-, 5-positions to 3-, 4-positions, intermolecular forces weaken and these compounds become liquid crystalline and show columnar rectangular mesophase resulting from the effect of regioisomerism. Moving on to the series with three alkoxy chains, it was observed that 2-, 3-, 4-trialkoxy substituted compounds exhibit columnar rectangular mesophase except lower chain length (n = 6 & 8) while 3-, 4-, 5-trialkoxy substituted aroylhydrazones show columnar rectangular mesophase; except n = 10 which shows columnar oblique mesophase. Thus it was established that on increasing density of alkoxy chains around one terminal, mesophase changes from smectic to columnar mesophase. Temperature dependent Raman studies confirm the presence of intermolecular hydrogen bonding. Further, effect of substitution pattern did not show much influence on the photophysical properties of the mesogenic series in solid and solution state. However, the non-mesogenic series showed a different absorption and emission transition from the mesogenic series in solid and solution state. Solid state fluorescence studies show almost similar emission maxima in all the series. However, it was also noticed that non-mesogenic series show maximum red shifted emission maxima in solid state as compared to that of solution. All the series showed good gelation properties with less than 1% CGC (wt%) suggesting the strong ability of molecules to form gel. These H-bonded liquid-crystalline gels have immense potential for applications in emissive displays.
- Kanth, Priyanka,Singh, Hemant Kumar,Kumar, Vijay,Singh, Sachin Kumar,Rao, D.S. Shankar,Prasad, S. Krishna,Singh, Bachcha
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- STEREOSELECTIVE SYNTHESIS AND PROCESS FOR THE MANUFACTURING OF 2'-DEOXYNUCLEOSIDES
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Methods for stereoselective synthesis and manufacturing of 2'-deoxynucleosides, such as 2'-ribonucleosides, are disclosed. In some embodiments, the 2'-deoxynucleoside is a β-anomer of 2'-deoxynucleoside having a 3' a hydroxyl, 4' β hydroxymethyl configuration. Nonlimiting examples of compounds prepared by the disclosed methods include 4'-thio-2'-deoxycytidine (T-dCyd) and 5-aza-4'-thio-2'-deoxycytidine (5-aza-T-dCyd; aza-T-dCyd; aza-T-dC).
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Page/Page column 23
(2019/08/26)
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- Preparation of near-infrared dye based on aza-fluoroborane and application
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The invention discloses preparation of near-infrared dye based on aza-fluoroborane and application. The near-infrared dye is prepared from thiophene-containing groups and a basic aza-fluoroborane framework. The aza-fluoroborane dye is prepared by the foll
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Paragraph 0036-0039
(2018/06/26)
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- Near-infrared chlorinated aza-boron fluoride dye, and preparation method and application of dye
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The invention discloses a near-infrared chlorinated aza-boron fluoride dye. In a preparation process of the dye, a chlorine substituted basic aza-boron fluoride framework is finally prepared by a multi-step reaction such as a synthesis-addition reaction-c
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Paragraph 0032; 0033; 0036; 0037
(2018/09/28)
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- The metal complex, a chiral nematic liquid crystal composition and crystal (by machine translation)
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[Problem] helical twisting power (βM ) Is increased, and, compatibility with a large metal complex of a nematic liquid crystal, chiral nematic liquid crystal composition using the same, and a liquid crystal element. (1) Or formula (2) represented by the formula [a] complex. (1) Or formula (2) in the metal complex represented by formula having chirality, nematic liquid crystal compounds containing chiral nematic liquid crystal compositions. Chiral nematic liquid crystal composition is filled between a pair of liquid crystal element. (R is C1 a-20 straight chain alkyl group or an alkoxy group of straight chain C1 a-20)[Drawing] no (by machine translation)
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Paragraph 0056; 0057
(2019/03/01)
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- Mesomorphism dependence on central bridge and tail ended polar group
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A novel azoester homologous series of laterally and terminally substituted viz, RO–C6H4–CH=CH–COO–C6H3–(CH3) –N=N–C6H4–Cl is synthesized, characterized and studied with a view to understand and establish the relation between molecular structure and thermotropic liquid crystalline property of its homologs. Series consists of twelve homologs. LC properties commence from very first member of a series and continue up to last homolog as enantiotropic nematic with absence of smectic property even in the monotropic condition. Transition temperatures of homologs were determined by polarizing optical microscopy equipped with a heating stage. The transition curves Cr?N and N?I behaved in normal manner. Thermal stability for nematic is 196.7?C whose mesophaselength ranges from 35°C to 131°C.
- Ranchchh, Avani R.,Chavda, Kavita,Bhanderi, Roshani,Patel, Suman,Bhoya
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- Mesomorphism dependence on molecular rigidity and flexibility
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A novel homologous series of liquid crystalline properties is synthesized and studied with a view to understand the effect of molecular structure on its thermotropic properties. Novel homologous series consisted of thirteen homologs. All the homologs are enantiotropically smectogenic with absence of nematic property even in the monotropic condition. Textures of the homologs as observed through an optical hot stage polarizing microscopy. The mesophase temperature range vary minimum from 6.0°C to a maximum 37.0°C at the methyloxy and propyloxy derivatives of a series respectively with its thermal stability (Sm–I) 127.0°C. Transition curves of a phase diagram behaved in normal manner. Odd–even effect is observed for Sm–I transition curve.
- Ranchchh, Avani R.,Bhoya
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- “Dependence of Mesomorphism in Combination with Fluoro and Chloro Groups”
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A novel azoester homologous series with chloro lateral group and a fluoro terminal end group was synthesized and characterized for mesomorphic properties. It consists of thirteen azo ester derivatives from trans-4-n-alkoxy cinnamic acid with 4-hydroxy-3-chloro phenyl azo-3-chloro-4-fluoro benzene. Mesomorphic property commences from C4homologue as smectic.C1 to C3 member of the series are non-mesomorphic. C4 to C18 homologous are enantiotropic smectic A phase. The nematic mesophase is totally absent. Texture and transition temperatures of the homologues are determined by an optical polarizing microscopy equipped with heating stage. 1H NMR, IR spectra, mass spectra, of some member is included. The spectroscopic analysis supports the molecular structure. A phase diagram is used to illustrate the mesomorphic behaviour across the series. Mesophaselength for smectic is varying from18.0°C to 69.00C. Mesomorphic properties of the novel azoester series are compared with structurally similar series.
- Ranchchh, Avani R.,Tharesha, Bhavna R.,Bhoya
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- Ferroelectric Liquid Crystals: Synthesis and Thermal Behavior of Optically Active, Three-Ring Schiff Bases and Salicylaldimines
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The chiral ferroelectric smectic C (SmC*) phase, characterized by a helical superstructure, has been well exploited in developing high-resolution microdisplays that have been effectively employed in the fabrication of a wide varieties of portable devices. Although, an overwhelming number of optically active (chiral) liquid crystals (LCs) exhibiting a SmC* phase have been designed and synthesized, the search for new systems continues so as to realize mesogens capable of meeting technical necessities and specifications for their end-use. In continuation of our research work in this direction, herein we report the design, synthesis, and thermal behavior of twenty new optically active, three-ring calamitic LCs belonging to four series. The first two series comprise five pairs of enantiomeric Schiff bases whereas the other two series are composed of five pairs of enantiomeric salicylaldimines. In each pair of optical isomers, the configuration of a chiral center in one stereoisomer is opposite to that of the analogous center in the other isomer as they are derived from (3 S)-3,7-dimethyloctyloxy and (3 R)-3,7-dimethyloctyloxy tails. To probe the structure–property correlations in each series, the length of the n-alkoxy tail situated at the other end of the mesogens has been varied from n-octyloxy to n-dodecyloxy. The measurement of optical activity of these chiral mesogens was carried out by recording their specific rotations. As expected, enantiomers rotate plane polarized light in the opposite direction but by the same magnitude. The thermal behavior of the compounds was established by using a combination of optical polarizing microscopy, differential scanning calorimetry, and powder X-ray diffraction. These complementary techniques demonstrate the existence of the expected, thermodynamically stable, chiral smectic C (SmC*) LC phase besides blue phase I/II (BPI or BPII) and chiral nematic (N*) phase. However, as noted in our previous analogous study, the vast majority of the Schiff bases show an additional metastable, unfamiliar smectic (SmX) phase just below the SmC* phase. Notably, the SmC* phase persists over the temperature range ≈80–115 °C. Two mesogens chosen each from Schiff bases and salicylaldimines were investigated for their electrical switching behavior. The study reveals the ferroelectric switching characteristics of the SmC* phase featuring the spontaneous polarization (PS) in the range 69–96 nC cm?2. The helical twist sense of the SmC* phase as well as the N* phase formed by a pair of enantiomeric Schiff bases and salicylaldimines has been established with the help of circular dichroism (CD) spectroscopic technique. As expected, the SmC* and the N* phase of a pair of enantiomers showed mirror image CD signals. Most importantly, the reversal of helical handedness from left to right and vice versa has been evidenced during the N* to SmC* phase transition, implying that the screw sense of the helical array of the N* phase and the SmC* phase of an enantiomer is opposite.
- Veerabhadraswamy, Bhyranalyar N.,Rao, Doddamane S. Shankar,Yelamaggad, Channabasaveshwar V.
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supporting information
p. 1012 - 1023
(2018/04/23)
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- Ethynyl bridging based A-phi-D-phi-A type BODIPY derivative and preparation method thereof
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The invention discloses an ethynyl bridging based A-phi-D-phi-A type BODIPY derivative and a preparation method thereof. The A-phi-D-phi-A type BODIPY derivative is prepared by the following steps: grafting ethynyl to groups such as fluorene, carbazole, d
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Paragraph 0059; 0060
(2017/08/02)
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- D-pai-A-pai-D type BODIPY (boron-dipyrromethene) derivatives based on acetenyl bridging and preparation method of D-pai-A-pai-D type BODIPY derivatives
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The invention discloses D-pai-A-pai-D type BODIPY (boron-dipyrromethene) derivatives based on acetenyl bridging and a preparation method of the D-pai-A-pai-D type BODIPY derivatives. The derivatives are novel and are obtained by linking acetenyl to fluori
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Paragraph 0068; 0069
(2017/07/20)
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- A two-dimensional molecule with a large conjugation degree: Synthesis, two-photon absorption and charge transport ability
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A new molecule, 5,5′-bis(4,6-bis((E)-4-(octyloxy)styryl)pyrimidin-2-yl)-2,2′-bithiophene (OSPB), was designed and synthesized. It contains two D-π-A-π-D (donor-π-acceptor-π-donor) segments with an alkoxy group D and a pyrimidine moiety A, and these two segments are connected through a bithiophene moiety to shape a two-dimensional (2D) multibranched conjugated system. The molecule showed high thermal stability. It demonstrated good solubility in THF with an emission maximum at 470 nm, and excimer emission appeared in poor solvents such as aqueous media showing an obvious red-shift. A two-photon excited fluorescence (TPEF) test revealed that the maximal two-photon absorption (2PA) cross-section of the molecule was 1352 GM, which is comparable with the reported bipyrimidine-based multibranched compounds with a stronger donor. Theoretical calculation suggested that the molecule showed good coplanarity made up by two conjugated segments with a small dihedral angle. The charge transport ability of OSPB was preliminarily studied using an organic thin-film transistor (OTFT) device via a low-cost solution processing technique, and the results demonstrated that it was a p-type semiconductor.
- Chen, Dugang,Zhong, Cheng,Zhao, Yan,Nan, Lingyan,Liu, Yunqi,Qin, Jingui
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supporting information
p. 5199 - 5206
(2017/07/10)
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- Efficient and practical method for the synthesis of hydrophobic azines as liquid crystalline materials
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A series of hydrophobic symmetrical azines: 1,2-bis[4-(n-alkoxy)benzylidene]hydrazine (where, n-alkoxy: O(CH2)nH, n = 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 16, or 18) have been prepared following an efficient and practical method. These compounds have been synthesized via the condensation reaction of hydrazine hydrate and appropriately 4-(n-alkoxy) benzaldehydes in acidic medium under ambient conditions. The prepared organic compounds have been characterized and their structures were elucidated depending upon micro-elemental analysis and spectral data (IR, UV-Vis, 1HNMR, 13C{1H}NMR, 2D 1H-1H-cozy, 2D 1H-13C-HSQC, and mass spectra). Liquid crystalline behavior of the prepared compounds was studied using polarized light optical microscopy and differential scanning calorimetry techniques. This study revealed that all the compounds displayed enantiotropic liquid crystal properties, exhibiting smectic and nematic mesophases.
- Hammood, Ali Jasim,Kased, Ahmed Fadhel H.,Al-Karawi, Ahmed Jasim M.,Raseen, Sameem R.,Tomi, Ivan Hameed R.,Omar Ali, Al-Ameen Bariz
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p. 114 - 129
(2017/07/04)
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- Mesogenic naphthyl derivatives
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Two new mesogenic homologous series of liquid crystalline naphthalene derivatives with different central linkages: 2- Naphthyl-4-n-alkoxybenzoates (I) and trans-2-Naphthyl -4-n –alkoxycinnamates(II), have been synthesized and characterized by a combination of elemental analysis and standard spectroscopic methods. Twelve compounds have been synthesized in both the series I and II. In series I, methoxy to n-pentyloxy derivatives are non mesogenic, n-hexyloxy to n-hexadecyloxy derivatives exhibit monotropic nematic mesophase. Smectic A mesophase commences from n-decyloxy derivatives as a monotropy and persist up to the last member synthesized. All the 12 compounds of series II exhibit mesomorphism. Methoxy to n-propyloxy derivatives exhibit monotropic nematic mesophse, and n-butyloxy to n-tetradecyloxy derivatives exhibit enantiotropic nematic mesophase. n-Hexayloxy to n-hexadecyloxy derivatives also exhibit enantiotropic smectic A mesophase. The mesomorphic properties of present series were compared with each other and with a structurally related mesogenic homologous series to evaluate the effects of central linkage on mesomorphism.
- Patel,Prajapati
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p. 106 - 115
(2017/03/08)
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- Study the effects of terminal side chain and –nitro group on mesomorphic behaviour of cinnamate-chalconyl based liquid crystal
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The influence of the terminal side chain and lateral nitro on mesomorphism due to the flexibility and polarity of lateral group is investigated. A new homologues series is synthesized to accomplish this aim. The C1 to C3 homologue are nonmesomorphic, while the rest of the homologues exhibit enantiotropic nematic and smectic properties. The texture of the nematic mesophase is of threaded, Schlieren and droplets type. All these compounds were characterized by elemental analyses and spectroscopic techniques of FTIR and 1H Nuclear magnetic resonance (NMR). The phase behaviour was studied by polarizing optical microscopy (POM), differential scanning calorimetry (DSC), and X-ray diffraction techniques.
- Sharma, Vinay S.,Patel
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- Mesomorphic study of novel chalconyl-ester-based nonisomeric series: Synthesis and characterization
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A newly designed homologues series: 3-(3-(4-(Dimethylamino) phenyl) acrylonyl) phenyl 3-(4-n-alkoxyphenyl) acrylate has been synthesized and studied through chalconyl ester linking group at (meta) position. The series consists of 13 compounds, in which C1 to C4 homologue are nonliquid crystal, while C5 to C18 exhibit nematic phase, and C12 to C18 shows smectic and nematic phase with enantiotropically manner. Mesophase image of present compounds are rod like, needle and threaded type textures investigated by POM. All this compounds were characterized by elemental analysis, FT-IR and 1H NMR. The mesomorphism is measured by POM, DSC, and molecular packing is determined by XRD technique. The following synthesized chalconyl ester-based compounds C5 to C12 shows antibacterial as well as antifungal activity compared with corresponding standard drugs. Analytical and spectral data confirmed the molecular structures of homologous series.
- Sharma, Vinay S.,Patel
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- Tuning the mesomorphic properties of nonisomeric chalconyl-ester bases homologous series: The effect of tail group
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The mesomorphic properties of nonlinear chalconyl ester homologous series can be tuned in a predictable fashion with tail groups (-OC16H33) substituents on the terminal side. Novel series consisted thirteen members (C1–C8, C10, C12, C14, C16, C18). C1 to C5 homologues are nonliquid crystal, C6 to C14 homologues shows nematic mesophase enantiotropically, while C16, C18 exhibits smectic as well nematic properties. The texture of the nematic mesophase is of fan shaped, schlieren and nematic droplets type. All these compounds were characterized by elemental analyses and spectroscopic techniques such as [FTIR] and 1H Nuclear magnetic resonance [NMR] spectroscopy. The mesomorphic properties of these compoundswere observed by optical polarized light microscopy (POM) and differential scanning calorimetry (DSC).
- Sharma, Vinay S.,Patel
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- Synthesis and study of mesomorphic properties in rod-like chalconyl compounds
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In order to investigate the influence of the central linking group and effect on flexibility on mesophase behavior of liquid crystal we have synthesized newly homologous series viz. 3-(4-Octyloxyphenyl)-1-(4′-n-alkoxy phenyl) prop-2-en-1-one (Series-l) consists of thirteen homologues (C1 to C8, C10, C12, C14, C16, C18). Textures of a nematic phases are threaded or Schlieren type. The textures of smectic and nematic phase are directly judged from the heating and cooling condition. Group efficiency order for mesophases is derived on the basis of thermal stabilities from the comparative study of thermometric data determined from structurally analogous series. A transition curve as depicted in a phase diagram behaves in normal manner. Structural and conformational characterization of these new compounds had achieved by 1H NMR, 13C NMR, IR, and elemental analysis.
- Sharma, Vinay S.,Patel
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- Synthesis and mesomorphic properties of new chalconyl-linkage-based liquid crystal compounds: The effect of flexibility
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A new series of liquid crystals involving chalconyl-based mesogenic units interlinked between two benzene cores were designed and synthesized. The target chalconyl compounds were obtained by the reaction of 4-n-alkoxy benzaldehyde with 4-n-hexadecyloxy (–OC16H33) acetophenone in presence of base. The liquid crystalline properties of synthesized compounds were observed by polarizing optical microscope study. The molecular structures of the compounds were confirmed by Fourier transform infrared, 1H, and 13C nuclear magnetic resonance spectra. The compounds of the series C3 to C8, C10, C12, C14, C16, and C18 exhibited mesophase in enantiotropically manner. The transition temperature reduced as alkyl spacer of left side group increased. The observed texture images are droplets, broken fan, and threaded like. Thermal stability of current homologous series for (N-I/I-N) is 69.8°C and for smectic phase (Sm + N) is 58.0°C.
- Sharma, Vinay S.,Patel
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p. 129 - 140
(2017/03/08)
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- Molecular flexibility dependence on mesogenic behaviors of isomeric and nonisomeric series
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A novel homologous series containing vinyl ester and azomethane central bridges and n-alkoxy as well as 3″,4″-dimethyl groups as flexible terminal/lateral groups viz. RO?C6H4?CH = CH?COO?C6H4?N?CH?C6H3-(CH3)2 have been synthesized and studied with a view to establishing the relation between molecular structure and thermotropic liquid crystal (LC) properties with reference to molecular flexibility within the series. The series consists of twelve homologues (C1 to C16). C6 and C7 homologues are smectogenic plus nematogenic and C8 to C16 homologues are only smectogenic, and the rest of the homologues (C1 to C5) are nonmesomorphic. Transition temperatures and the textures of the homologues were determined using an optical polarizing microscope equipped with a heating stage (POM). The textures of a nematic phase are threaded or Schlieren and that of a smectic phase are of the A or C type. Analytical, thermal and spectral data support the molecular structures. Smectic and nematic thermal stabilities are 116.85°C and 147.5°C, respectively. Whose Sm?N/I and N-I mesophase lengths are varied between 15°C to 21°C and 25°C to 62°C, respectively. The novel compounds are compared with structurally-similar series.
- Rakhasia,Ranchchh, Avani R.,Bhoya
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p. 159 - 167
(2017/03/08)
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- Mesomorphism dependence on molecular rigidity and substitution of same functional group on lateral or terminal position of tailed phenyl ring
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Novel liquid crystal materials (LCs) of low temperature range (53°C to 75°C) have been synthesized through a series of chalconyl derivatives consisting of two phenyl rings bonded through a –CH?CH?CO? central bridge to study the effect of molecular structure on LC properties in general and with a focus on molecular rigidity. The novel homologues series (C1 to C18) consists of thirteen homologues with general formula RO?C6H4?CH?CH?CO?C6H4?OC10H21(n) (meta). The C1, C2, C3 homologues are nonliquid crystals (NLC) and the rest of the homologues (C4 to C18) are either monotropic or enantiotropic liquid crystals. C4 to C6 homologues are enantiotropicnematic and the rest of the mesomorphic homologues are (C7 to C18) monotropicsmectic in addition to monotropicnematic character. Transition and melting temperatures including textures of homologues were determined by an optical polarizing (POM) microscopy equipped with a heating stage. Textures of a nematic phase are threaded or Schlieren, and that of the smectic phase are of the type Smectic A or C as judged directly from the heating top of the microscope. Thermal stability for smectic is very poor and of the nematic is (N-I) 69.3°C whose, total mesophase length ranges between 07.0 to 14.0°C at C8 and C4 homologues respectively.
- Sharma, Vinay S.,Patel
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p. 178 - 187
(2017/03/08)
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- The effect of position of octadecyloxy tail on the formation of liquid crystal with chalconyl-ester and chalconyl-vinyl ester series: Comparison with corresponding linkage group
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Two series of chalconyl-based liquid crystals which differ from each other in the position of the first linking group have been synthesized and characterized by elemental analyses and spectroscopic techniques such as Fourier transform infrared and proton magnetic resonance magnetic resonance [1H NMR] spectroscopy. The mesomorphic properties of these compounds were observed by optical polarized light microscopy (POM) and differential scanning calorimetry (DSC). We have synthesized two homologous series viz. 3-(3-(4-(Octadecyloxy) phenyl) acrylonyl) phenyl 3-(4-n-alkoxyphenyl) acrylate (series-1) and 3-(3-(4-(Octadecyloxy) phenyl) acryloyl) phenyl 4-n-alkoxy benzoate (series-2). Series-1 has chalconyl-ester central linkage group while in series-2 chalconyl-vinyl ester group is present and tail octadecyloxy side chain is common in both homologous series. All the homologous in present series display LC property in enantiotropical manner except first three homologous in both series.
- Solanki,Sharma, Vinay. S.,Patel
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p. 216 - 232
(2017/03/08)
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- Synthesis, characterization, and mesomorphic investigation of vinyl ester-substituted chalcones and effect of lateral ?NO2 and ?OCH3 group
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A novel homologous series of α-4-(4′-n-alkoxy cinnamoyloxy) phenyl β-2″-nitro, 3″–4″ di methoxy benzoyl ethylenes, H2n + 1CnO?C6H4?CH?CH?COO?C6H4?CO?CH?CH?C6H2(NO2) (OCH3)2 (n = 1–8, 10, 12, 14, 16, 18) has been synthesized. All these compounds have been characterized by suitable spectroscopic techniques. C1 homologue is nonmesogenic, while C2 homologue shows enantiotropic nematogenic property and the rest of the homologous (C3?C18) displayed enantiotropically smectogenic plus nematogenic phase. Phase transition temperatures and textures of the LC phase were determined by an optical polarizing microscopy (POM) equipped with a heating stage. The mesomorphic properties of these compounds were confirmed by differential scanning calorimetry (DSC) analysis.
- Sharma, Vinay S.,Patel
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p. 241 - 251
(2017/03/08)
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- Synthesis and mesomorphic properties of new chalconyl-ester based liquid crystals: The effect of tail group
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A new homologous series viz. 4-(3-(3, 4-dioctadecyloxy) phenyl)-3- oxoprop-1-en-1-yl) phenyl-3-(4-n-alkoxy phenyl) cinnamate) based on two linking groups have been synthesized and characterized. The mesomorphic properties of these compounds were observed by optical polarized light microscopy (POM) and confirmed by differential scanning calorimetry (DSC). All synthesized compounds exhibited LC behaviour except compound C1. Thermal stability of smectic and nematic phase of present series are 79.0°C and 120.0°C whose temperature range is vary from 14 to 20°C and 24 to 56°C respectively. The mesomorphic properties of present series were compared with other structurally related mesogenic homologous series to evaluate the effects of tail group on mesomorphism.
- Sharma, Vinay S.,Vekariya, Rajesh H.,Sharma, Anuj S.,Patel
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- Alkoxy substituted D-π-A dimethyl-4-pyrone derivatives: Aggregation induced emission enhancement, mechanochromic and solvatochromic properties
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Three series of D-π-A 2,6-dimethyl-4-pyrone-cored derivatives were designed and synthesized. Evaluation by spectroscopic methods indicated that all the compounds exhibited aggregation-induced emission enhancement (AIEE) effect and solvatochromism. The experimental results revealed that the restriction of intramolecular rotation is the key element for showcasing the AIEE phenomenon. Moreover, all of the compounds presented red-shifted mechanochromic behavior, the extent of the red-shift was mainly dependent on the position and length of alkoxyl group. The PXRD and DSC profiles demonstrated a transformation from crystalline to amorphous state upon grinding. The D-A strategy introduced in this work could facilitate the development and application of ingenious mechanochromic materials.
- Cao, YuQi,Xi, Ye,Teng, XinYu,Li, Yang,Yan, Xilong,Chen, Ligong
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- Synthesis and mesomorphic properties of quinoline-8-yl-4-((4-n-alkoxy benzylidene) amino) benzoate: The effect of linkage group
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A new homologous series viz. quinoline-8-yl-4-((4-n-alkoxy benzylidene) amino) benzoate based on two central linking groups have been designed and characterised by elemental analyses and spectroscopic techniques such as Fourier transform infrared [FT-IR] and protonmagnetic resonance magnetic resonance [1H NMR] spectroscopy. The mesomorphic properties of these compounds were observed by polarizing optical light microscopy (POM) and confirmed by differential scanning calorimetry (DSC). All synthesized compounds displayed LC property except first two homologue. The lower homologues (n = 4 to 8) display SmA and SmC phase while, in higher homologues (n = 10 to 18) SmC and nematic phasewere seen in heating and cooling condition.
- Sharma, Vinay. S.,Vekariya, Rajesh H.,Sharma, Anuj. S.,Patel
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- Synthetic pathway for a new calamitic series of liquid crystal: Comparison with corresponding linkage group
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Reduction-responsive cystamine-incorporated gelatin microspheres were prepared by an emulsification method. On SEM micrograph, the microsphere, prepared at pH 9.0 and at the carboxyl/amino group molar ratio of 1:1, was sphere-like and its diameter was a few to 100 μm. The gelatin to cystamine ratio of the microsphere was about 1:0.2 (w/w), determined by energy dispersive X-ray spectroscopy. Two endothermic peaks were observed around 92°C and 126°C, which were thought to be the melting point of gelatin-rich phase and that of cystamine-rich phase, respectively. The microsphere released its payload (FITC-dextran) in dithiothreitol (a reducing agent) concentration-dependent manner.
- Sharma, Vinay S.,Vekariya, Rajesh H.,Sharma, Anuj S.,Patel
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p. 143 - 157
(2017/10/27)
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- New hockey stick shaped amino allylidene (?N?CH?CH?CH) based compounds: Effect of linkage group on mesomorphic properties
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Two nonlinear hockey stick shaped homologous series based on three linking groups have been synthesized and characterized by elemental analyses and spectroscopic techniques. The mesomorphic properties of these compounds were observed by polarizing optical microscopy (POM) and differential scanning calorimetry (DSC). In this present investigation, we have synthesized two homologous series viz. 2-((3-phenyl allylidene) amino) phenyl 4-((4-n-alkoxy benzylidene) amino) benzoate (series-1) and 4-((2-((3-phenyl allylidene) amino) phenoxy) carbonyl) phenyl-4-n-alkoxy benzoate (series-2). Both the series are differing with respect to first linking group. In series-1, comp.C4-C18 shows nematic as well as smectic phase while in series-2, comp.C10-C16 shows smectic and nematic phase while comp.C4-C18 shows only nematic phase.
- Sharma, Vinay. S.,Vekariya, Rajesh. H.,Sharma, Anuj. S.,Patel
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- The effect of position of tert-butyl tail group on the formation of liquid crystal in Schiff base ester based homologous series
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We report a newly rod like calamatic liquid crystalline materials, which are constructed by the self-organization of a rod-like carboxylic acid derivative based on Schiff base ester as the linking group with tert butyl tail group. A newly series of 4-(tert-butyl) phenyl 4-((4-alkoxybenzylidene) amino) benzoate with different alkyl chain spacer (n = 1 to 8, 10, 12, 14, 16, and 18) were synthesized and their mesomorphic properties were investigated by differential scanning calorimetry and polarized optical microscopy. All homologous in present series displays mesophase in enantiotropically manner. Thermal stability of SmC-SmA is 137.5 °C. All the compounds were characterized by spectroscopic and elemental analysis. The effects of varying left alkyl side spacer on mesomorphism with its structurally related compounds in series have been discussed.
- Sharma,Patel
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- Novel A-D-A type small molecules with β-alkynylated BODIPY flanks for bulk heterojunction solar cells
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A serial of novel A-D-A type small molecules with BODIPY linked through alkynyl with various electron donor units such as fluorene, carbazole, benzodithiophene and phenothiazine, namely F-BDP, C-BDP, B-BDP and P-BDP, respectively, were designed and synthe
- Liao, Junxu,Xu, Yongjun,Zhao, Hongbin,Zong, Qiao,Fang, Yutang
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p. 321 - 333
(2017/07/12)
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- METAL ORGANIC LIQUID CRYSTAL DYES
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A dye composition dissolvable within a liquid crystal host device (including: polymer dispersed liquid crystal, polymer network liquid crystal, polymer stabilized liquid crystal, liquid crystal displays and similar devices), comprising eutectic mixtures o
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Paragraph 0064
(2018/01/14)
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- Median alkoxy phenyl substituted and 2, 6 site strong electron donating group substituted BODIPY (4,4'-difluoro-4-bora-3a,4a-diaza-sindacene) derivative and preparation method thereof
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The invention discloses a median alkoxy phenyl substituted and 2, 6 site strong electron donating group substituted BODIPY (4,4'-difluoro-4-bora-3a,4a-diaza-sindacene) derivative and a preparation method thereof. The preparation method comprises: synthesizing a median alkoxy phenyl substituted 2, 6-dibromo fluorine boron intermediate through a series of reactions; and performing Suzuki/Stille coupling reaction by using the intermediate and a variety of modified groups to obtain a median alkoxy phenyl substituted and 2, 6 site thiofuran, thienothiophene, fluorene, carbazole and other strong electron donating units substituted BODIPY derivatives. The absorption spectrum of the prepared target dye molecules generates obvious bathochromic shift, and the maximum absorption wavelength is lengthened to a near infrared area. The median alkoxy phenyl substituted and 2, 6 site strong electron donating group substituted BODIPY derivative has good stability, and has potential application values in the fields of life sciences, solar batteries, environment energy sources and the like.
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Paragraph 0022
(2016/10/10)
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- Novel organic dye sensitizer containing BODYPY type conjugate units and preparation method of sensitizer
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The invention discloses a novel organic dye sensitizer containing BODYPY type conjugate units and a preparation method of the sensitizer. The novel organic dye sensitizer is an organic light-sensitive dye of a D-pi-pi-A structure, a BODYPY nuclear bridging phenyl group substituted at the meso- site serves as the pi bridge framework, a triphenylamine derivative serves as the electron giver unit, and cyanoacetic acid serves as the electron receptor unit. The invention further discloses a preparation method of the organic dye sensitizer. Organic dye sensitizer molecules are obtained through the two-step Suzuki coupling reaction and the one-step Knoevenagel condensation reaction, and the structural general formula is seen in the formula I (please see the formula I in the description). The organic dye sensitizer is simple in molecule synthesis method, easy to control and high in yield and has general applicability, and a dye sensitive solar cell material with excellent performance can be obtained after the organic dye sensitizer is applied to preparation of a dye sensitive solar cell.
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Paragraph 0058; 0059
(2017/02/02)
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- Fluorene and carbazole bridging-based A-D-A type double-center BODIPY (boron-dipyrrolemethene) derivative and preparation method for same
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The invention discloses a fluorene and carbazole bridging-based A-D-A type double-center BODIPY (boron-dipyrrolemethene) derivative and a preparation method for the same. A novel double-center BODIPY derivative I containing different bridging groups such
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Paragraph 0048; 0049
(2017/10/27)
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- Acetylenic Scaffolding with Subphthalocyanines
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A new boron subphthalocyanine (SubPc) derivative with a terminal alkyne substituent on the central boron atom was prepared by substitution of a triflate at the boron atom with but-3-yn-1-ol. This compound was shown to be a versatile building block for metal-catalyzed coupling reactions, such as modified Glaser-Hay, Cadiot-Chodkiewicz, and Sonogashira reactions as well as the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). For example, metal-catalyzed reactions provided access to a SubPc dimer containing a butadiyne bridging unit, two different SubPc-fullerene dyads as well as two cross-conjugated SubPc-tetraethynylethene (TEE) scaffolds. These TEEs containing two silyl-protected alkyne units are potential building blocks for further acetylenic scaffolding. The work shows how the axial position is post-functionalized in steps not involving a substitution reaction at the central boron atom, which is otherwise often used as the terminal step in axial functionalization of SubPcs.
- Gotfredsen, Henrik,Jevric, Martyn,Kadziola, Anders,Nielsen, Mogens Brondsted
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supporting information
p. 17 - 21
(2016/01/20)
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- 8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells
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Ras converting enzyme 1 (Rce1) is an endoprotease that catalyzes processing of the C-terminus of Ras protein by removing -aaX from the CaaX motif. The activity of Rce1 is crucial for proper localization of Ras to the plasma membrane where it functions. Ras is responsible for transmitting signals related to cell proliferation, cell cycle progression, and apoptosis. The disregulation of these pathways due to constitutively active oncogenic Ras can ultimately lead to cancer. Ras, its effectors and regulators, and the enzymes that are involved in its maturation process are all targets for anti-cancer therapeutics. Key enzymes required for Ras maturation and localization are the farnesyltransferase (FTase), Rce1, and isoprenylcysteine carboxyl methyltransferase (ICMT). Among these proteins, the physiological role of Rce1 in regulating Ras and other CaaX proteins has not been fully explored. Small-molecule inhibitors of Rce1 could be useful as chemical biology tools to understand further the downstream impact of Rce1 on Ras function and serve as potential leads for cancer therapeutics. Structure-activity relationship (SAR) analysis of a previously reported Rce1 inhibitor, NSC1011, has been performed to generate a new library of Rce1 inhibitors. The new inhibitors caused a reduction in Rce1 in vitro activity, exhibited low cell toxicity, and induced mislocalization of EGFP-Ras from the plasma membrane in human colon carcinoma cells giving rise to a phenotype similar to that observed with siRNA knockdowns of Rce1 expression. Several of the new inhibitors were more effective at mislocalizing K-Ras compared to a potent farnesyltransferase inhibitor (FTI), which is significant because of the preponderance of K-Ras mutations in cancer.
- Mohammed, Idrees,Hampton, Shahienaz E.,Ashall, Louise,Hildebrandt, Emily R.,Kutlik, Robert A.,Manandhar, Surya P.,Floyd, Brandon J.,Smith, Haley E.,Dozier, Jonathan K.,Distefano, Mark D.,Schmidt, Walter K.,Dore, Timothy M.
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p. 160 - 178
(2015/12/31)
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- On–off Bodipy chemosensor for recognition of iron(III) ion based on the inner filter effect and its applications in cellular and bacterial imaging
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One strong fluorescent Bodipy-containing derivative was synthesized and characterized using 1H NMR, electrospray ionization mass spectrometry and elemental analysis. Its electrochemical and photophysical properties were investigated. In additio
- Kong, Lingcan,Lu, Keyu,Ma, Guangyuan,Yao, Yuyang,Ling, Xia,Liu, Wenwei
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p. 1448 - 1455
(2016/12/07)
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- Implications of flexible spacer rotational processes on the liquid crystal behavior of 4,5-dihydroisoxazole benzoate dimers
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The synthesis of some novel non-symmetric liquid crystal dimers, {3-[4-(octyloxyphenyl)]-4,5-dihydroisoxazol-5-yl}alkyl 4-(decyloxy)benzoates (5a-d) and 4-{3-[4-(octyloxyphenyl)]-4,5-dihydroisoxazol-5-yl}alkyl 4-{[6-(octyloxy)naphthalen-2-yl]ethynyl}benzo
- Tavares, Aline,Toldo, Josene M.,Vilela, Guilherme D.,Gon?alves, Paulo F. B.,Bechtold, Ivan H.,Kitney, Stuart P.,Kelly, Stephen M.,Merlo, Aloir A.
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p. 393 - 401
(2016/01/12)
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