- Novel 4-methylumbelliferone amide derivatives: Synthesis, characterization and pesticidal activities
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A series of novel 4-methylumbelliferone amide derivatives were designed, synthesized and characterized by 1H NMR, 13C NMR and HR-ESI-MS. The structures of compounds 4bd and 4be (compounds named by authors) were further confirmed by X-ray single crystal diffraction. The acaricidal, herbicidal and antifungal activities of the synthesized compounds were assayed for their potential use as pesticide. The results indicated that compounds 4bi, 4ac and 4bd were strong acaricidals against Tetranychus cinnabarinus, with 72h corrected mortalities of greater than 80% at 1000 mg/L. Meanwhile, compounds 4bh and 4bf exhibit the strongest inhibition against the taproot development of Digitaria sanguinalis and Chenopodium glaucum, and were even more potent than the commercial herbicide Acetochlor against D. sanguinalis. In addition, compounds 4bk, 4bh and 4bp showed the highest antifungal activity against the mycelium growth of Valsa Mali, which makes them more effective than commercial fungicide Carbendazim.
- Wei, Yan,Miao, Kai-Long,Hao, Shuang-Hong
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- New angular oxazole-fused coumarin derivatives: synthesis and biological activities
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Twelve angular oxazole-fused coumarin derivatives were designed, synthesised and characterised by 1H NMR, 13C NMR and HRMS. The structure of compound 4a was further confirmed by X-ray single-crystal diffraction. The bioassay experiment results indicated that compounds 4f and 4l have high antifungal activity on the mycelium growth of 4 plant disease fungi. Especially, compound 4l has a stronger antifungal activity compare to the commercial fungicide, Carbendazim. The herbicidal activity experiment showed that 4a and 4b can significantly inhibit the taproot and caulis development of Chenopodium album seedling and have better activities than the commercial herbicide, Acetochlor.
- Wei, Yan,Li, Shi-qiang,Hao, Shuang-hong
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p. 1824 - 1831
(2017/11/28)
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- Synthesis and biological evaluation of coumarinyl sydnone derivatives
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A novel series of compounds containing coumarinyl sydnone derivatives from 4-methyl-7-hydroxy-8-nitro coumarin were synthesized. The formed compounds have been evaluated by physical methods (melting point, thin layer chromatography, elemental analysis) an
- Patel, Keshav C.,Patel, Himanshu D.
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p. 113 - 118
(2012/02/03)
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- Synthesis of novel amino and acetyl amino-4-methylcoumarins and evaluation of their antioxidant activity
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The six novel 4-methylcoumarins bearing different functionalities such as amino, hydroxy, N-acetyl, acetoxy and nitro have been synthesized and confirmed on the basis of their spectral data (1H-, 13C-NMR, UV, IR and EI mass). They were examined for the first time for their effect on NADPH dependent liver microsomal lipid peroxidation in vitro, and the results were compared with other model 4-methylcoumarin derivatives to establish the structure-activity relationship. Our studies demonstrated that amino group is an effective substitute for the hydroxyl group for antioxidant property and produced a dramatic inhibition of lipid peroxidation. Ortho dihydroxy and ortho hydroxy-amino coumarins were found to possess highest antioxidant and radical scavenging activities.
- Tyagi, Yogesh K.,Kumar, Ajit,Raj, Hanumantharao G.,Vohra, Parag,Gupta, Garima,Kumari, Ranju,Kumar, Pankaj,Gupta, Rajinder K.
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p. 413 - 420
(2007/10/03)
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