Synthesis of stereoisomers of 4-bromo- and 4-iodo-N-phthaloylglutamates based on the bromination of N-phthaloylglutamic acid followed by separation of diastereoisomers is described.
Stereoselective synthesis of γ-hydroxy-α-amino acids through aldolase-transaminase recycling cascades
Efficient bi-enzymatic cascades combining aldolases and α-transaminases were designed for the synthesis of γ-hydroxy-α-amino acids. These recycling cascades provide high stereoselectivity, atom economy, and an equilibrium shift of the transamination. l-syn or anti-4-hydroxyglutamic acid and d-anti-4,5-dihydroxynorvaline were thus prepared in 83-95% yield in one step from simple substrates.
Synthesis of 4,4-Disubstituted L-Glutamic Acids by Enzymatic Transamination
The syntheses of optically pure 4,4-dimethyl-L-glutamic acid as well as (2S,4R)- and (2S,4S)-4-hydroxy-4-methylglutamic acids have been achieved by transamination of the corresponding 2-oxo-4,4-dimethyl- and rac-2-oxo-4-hydroxy-4-methylglutaric acids using glutamic oxalacetic transaminase (GOT).
Helaine, Virgil,Rossi, Joel,Gefflaut, Thierry,Alaux, Sebastien,Bolte, Jean
p. 692 - 697
(2007/10/03)
STEREOSPECIFIC SYNTHESIS OF ENANTIOMERS OF 4-HYDROXYGLUTAMIC ACID AND STUDY OF THEIR INHIBITING PROPERTIES WITH RESPECT TO GLUTAMINE SYNTHETASE
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Krasnov, V. P.,Alekseeva, L. V.,Firsova, N. A.,Kodess, I. K.,Burde, N. L.
p. 369 - 372
(2007/10/02)
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