- (±)-3-indanone-1-acetic acid: Heterochiral catemeric hydrogen bonding in a δ-keto acid
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The crystal structure of (±)-2,3-dihydro-3-oxo-1H-indeneacetic acid, C11H10O3, involves carboxyl-to-ketone hydrogen-bonding catemers [O...O 2.691 (2) A] of an unusual type. Hydrogen bonds progress from the carboxyl H atom of one molecule to the ketone O (01) atom of a glide-related enantiomer, resulting in heterochiral chains. Parallel screw-related hydrogen-bonding chains proceed in counter-directional pairs through the cell. Two different close contacts (2.49 and 2.58 A) are found between the carboxyl C=O group and H atoms on neighboring molecules.
- Thompson, Hugh W.,Brunskill, Andrew P. J.,Lalancette, Roger A.
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- Sulfoxonium-Ylide-Directed C-H Activation and Tandem (4 + 1) Annulation
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Rh(III)-catalyzed C-H activation and cyclization of sulfoxonium ylide with acrylates leads to an efficient synthesis of indanone derivatives. The reaction proceeds under mild and external metal-oxidant-free conditions. The sulfoxonium ylide acts as a trac
- Hanchate, Vinayak,Devarajappa, Ravi,Prabhu, Kandikere Ramaiah
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p. 2878 - 2882
(2020/04/10)
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- Facile Synthesis of Spirocyclic Lactams from β-Keto Carboxylic Acids
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A facile synthesis of spirocyclic lactams starting from β-keto carboxylic acids via a one-pot cascade reaction involving a Curtius rearrangement and an intramolecular nucleophilic addition of the enol carbon to the isocyanate intermediate is reported. The same conditions have also been used for the generation of fused cyclic lactams with similar good yields. The synthetic value of this method has been demonstrated by efficient synthesis of tetracyclic spirolactam 8 and pentacyclic spirolactam 9.
- Yang, Wei,Sun, Xianyu,Yu, Wenbo,Rai, Rachita,Deschamps, Jeffrey R.,Mitchell, Lauren A.,Jiang, Chao,Mackerell, Alexander D.,Xue, Fengtian
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supporting information
p. 3070 - 3073
(2015/06/30)
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- Aminoindanes
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The present invention relates to therapeutically active novel aminoindanes of formula (I). Also provided is a method of preparing compounds of formula (I), and pharmaceutical compositions comprising the compounds. The novel compounds act as modulators of
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Page/Page column 28
(2010/02/05)
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- Application of the benzene sector and the benzene chirality rules to perhydrobenzocycloalkenes and related compounds
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Enantioenriched 1-substituted indans were prepared from (R)-1-indancarboxylic acid and (R)-1-indanylacetic acid as model compounds for the correlation of their absolute configurations with the sign of the 1Lb Cotton effects (CEs) from about 250 to 270 nm in their circular dichroism spectra. The CEs are the result of vibronic and induced contributions to the rotational strength, and their sign is in agreement with that predicted on the basis of the benzene sector and the benzene chirality rules. The application of these rules to other, nonplanar perhydrobenzocycloalkenes evolves into sector sign projections suggested earlier to correlate the sign of 1Lb CEs of enantiopure 1,2,3,4-tetrahydronaphthalenes and 1,2,3,4-tetrahydroisoquinolines with their absolute configurations.
- Lorentzen, Ronald J.,Brewster, James H.,Smith, Howard E.
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p. 2181 - 2187
(2007/10/02)
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