- Pyridine-containing m-phenylene ethynylene oligomers having tunable basicities
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Incorporation of a pyridine monomer into the backbone of a m-phenylene ethynylene oligomer allows functionalization of the interior binding cavity of the folded oligomer. The basicity of the inwardly directed pyridine moiety was modulated by changing the
- Heemstra, Jennifer M.,Moore, Jeffrey S.
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- Efficient synthesis of 4-amino-2,6-dichloropyridine and its derivatives
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A facile synthetic route to an important intermediate 4-amino-2,6-dichloropyridine was developed. Oxidation of 2,6-dichloropyridine as a starting material gave pyridine N-oxide derivative which was subjected to nitration followed by reduction. Subsequent nitration of the product and nucleophilic displacement reaction were carried out to afford fully substituted energetic pyridine derivatives. Most of the synthetic reactions proceeded under mild conditions.
- Ma, Congming,Liu, Zuliang,Yao, Qizheng
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p. 251 - 254
(2016/10/24)
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- FUSED PYRIDINE DERIVATIVES
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Fused pyridine derivatives shown as the general formula (I), and their pharmaceutically acceptable salts, stereoisomers or solvates thereof are disclosed, which belong to the technical field of medicines. The R1, R2, R3, Q, X and Y substituents in formula (I) are defined as in the description. Also disclosed are the preparation methods, pharmaceutical compositions comprising the compounds and uses of the compounds in the manufacture of the medicine for the treatment and/or prevention of noninsulin-dependent diabetes, hyperglycemia, hyperlipidemia and insulin resistance.
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- FUSED PYRIDINE DERIVATIVES
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Fused pyridine derivatives shown as the general formula (I), and their pharmaceutically acceptable salts, stereoisomers or solvates thereof are disclosed, which belong to the technical field of medicines. The R1, R2, R3, Q, X and Y substituents in formula (I) are defined as in the description. Also disclosed are the preparation methods, pharmaceutical compositions comprising the compounds and uses of the compounds in the manufacture of the medicine for the treatment and/or prevention of noninsulin-dependent diabetes, hyperglycemia, hyperlipidemia and insulin resistance.
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- 5-Substituted 1H-pyrrolo[3,2-b]pyridines as inhibitors of gastric acid secretion
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A series of novel 1H-pyrrolo[3,2-b]pyridines was prepared relying on a copper iodide catalyzed cyclization of 2-prop-1-ynylpyridin-3-amines. A structure-activity relationship was established focusing on the influence of the substitution pattern in position 1, 3, and 5 of the heterocycle on anti-secretory activity, lipophilicity, and pKa value. Some of the compounds proved to be potent inhibitors of the gastric acid pump.
- Palmer, Andreas Marc,Muench, Gabriela,Brehm, Christof,Zimmermann, Peter Jan,Buhr, Wilm,Feth, Martin Philipp,Simon, Wolfgang Alexander
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p. 1511 - 1530
(2008/09/18)
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- Design and Synthesis of a Series of Chlorinated 3-Deazaadenine Analogues
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A series of chlorinated adenine analogues were designed with sights set on the development of potential antitumor agents. During the synthetic efforts, two unexpected compounds were identified. Their synthesis, along with synthesis of the chlorinated targets is presented herein.
- Seley, Katherine L.,O'Daniel, Peter I.,Salima, Samer
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p. 2133 - 2144
(2007/10/03)
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- Phenoxy pyridine derivatives and herbicidal compositions containing same
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This invention relates to novel pyridine derivatives of the formula STR1 wherein n is 0, 1, or 2; R is an alkyl radical having from 1 to 4 carbon atoms, unsubstituted or substituted by one or more fluorine or chlorine atoms, alkenyl radical having from 2
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